| Japanese |
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| Title | 123I-IMPの経口および経直腸同時注入法による門脈循環動態の測定 |
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| Subtitle | 研究速報 |
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| Authors | 塩見進*, 黒木哲夫*, 植田正*, 小林絢三*, 池岡直子**, 門奈丈之**, 越智宏暢*** |
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| Organization | *大阪市立大学医学部第三内科, **公衆衛生, ***放射線科 |
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| Journal | 核医学 |
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| Volume | 27 |
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| Number | 1 |
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| Page | 45-49 |
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| Year/Month | 1990/1 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 123I-IMPを経口および経直腸投与し, 上腸間膜静脈および下腸間膜静脈からの門脈循環動態を同時に測定する方法を検討した. 腸溶カプセルにIMPを封入し経口投与した3時間後には, 大部分の症例でカプセルは小腸に達しており, 肝臓と肺のIMPのカウントは平衡状態になっていた. また経直腸から投与したIMPは, 20分後より肝臓と肺の比が一定に達しており, どちらの方法でも門脈循環動態の測定が可能であった. 慢性肝炎5例および肝硬変6例にこの方法を試みたところ, 慢性肝炎では経口法と経直腸法ではよく一致したが, 肝硬変では経口法は経直腸法に比べ低値を示す傾向にあった. 「I.はじめに」 著者らは, 門脈循環動態を測定する方法として経直腸門脈シンチグラフィを考案し, 一連の検討を加えてきた. この方法は非観血的に門脈循環動態の測定が可能であり, 画像的に門脈循環動態を把握できることより, 臨床的に有用な方法である. |
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| Practice | 臨床医学：一般 |
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| Keywords | Per-rectal portal scintigraphy, Oral portal scintigraphy, Enteric coated capsule, Portal systemic shunting |
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| English |
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| Title | Measurement of Portal Systemic Circulation by Oral and Per-rectal Administration of I-123 Iodoamphetamine |
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| Subtitle | |
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| Authors | Susumu SHIOMI*, Tetsuo KUROKI*, Tadashi UEDA*, Kenzo KOBAYASHI*, Naoko IKEOKA**, Takeyuki MONNA**, Hironobu OCHI*** |
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| Authors(kana) | |
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| Organization | *Third Department of Internal Medicine, **Department of Public Health, ***Department of Radiology, Osaka City University Medical |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 27 |
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| Number | 1 |
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| Page | 45-49 |
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| Year/Month | 1990/1 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] In an earlier study, we measured the portal circulation noninvasively by Tc-99m pertechnetate per-rectal portal scintigraphy. This method makes it possible to see the portal circulation and to diagnose portal hypertension from the images of the liver and heart. However, the method mainly reflects circulation from the inferior mesenteric vein, the contribution of which to the portal circulation is less than that of the superior mesenteric vein. Here, we devised capsules of I-123 iodoamphetamine (IMP) that dissolve when the pH changes to evaluate the portal circulation arising from the superior mesenteric vein. I-123 IMP enclosed in an enteric-coated capsule was prepared and given orally, just before I-123 IMP was injected into the rectum. The per-rectal portal shunt index (RSI) and oral portal shunt index (OSI) were calculated from the count of radioactivity of the liver and lungs. The RSI and OSI of patients with cirrhosis were both higher than those of the patients with chronic hepatitis. In individual patients, the RSI was higher than the OSI. This noninvasive method seemed to be useful in evaluation of the portal systemic circulation in chronic liver diseases. |
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| Practice | Clinical medicine |
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| Keywords | Per-rectal portal scintigraphy, Oral portal scintigraphy, Enteric coated capsule, Portal systemic shunting |
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