| Japanese |
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| Title | 123I-metaiodobenzylguanidineによる肥大型心筋症の評価 |
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| Subtitle | 原著 |
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| Authors | 中嶋憲一*, 分校久志*, 滝淳一*, 清水賢巳**, 南部一郎*, 村守朗*, 松成一朗*, 久田欣一* |
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| Authors(kana) | |
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| Organization | *金沢大学医学部核医学科, **第二内科 |
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| Journal | 核医学 |
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| Volume | 27 |
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| Number | 1 |
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| Page | 33-38 |
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| Year/Month | 1990/1 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 肥大型心筋症 (HCM) 29症例を対象に123I-metaiodobenzylguanidine (MIBG) を用いて, 心筋断層シンチグラフィ (SPECT) を行い, このうち高血圧を合併していない21症例について, 心筋の各セグメントのMIBGと201Tlの摂取率を計算した. 超音波検査上中隔の肥大を認める症例についてその壁厚を測定し, 中隔の関心領域上の摂取率との関係を検討したところ, MIBGの初期摂取率および201Tlの摂取率 (% injected dose/100cm3) は壁厚と正相関 (R=0.581, P=0.0058, およびR=0.677, P=0.0007) が得られた. 一方, MIBG摂取率を201Tlの摂取率で除して単位血流当たりのMIBG摂取率に換算すると (MIBG/Tl) , MIBG初期像, 後期像ともに壁厚と負の相関を示した (R=-0.485, P=0.0255およびR=-0.535, P=0.0125) . さらに心筋のMIBGクリアランスは壁厚と有意の正相関を認め (R=0.510, P=0.0182) , 特に中隔壁厚が高度 (>20mm) の群では, それ以下の群に比較して高値であった (13.4±8.0%/hr vs. 3.2±4.7%/hr, P=0.0028) . MIBGは心筋の交感神経活性の評価法として有用であるが, 特にクリアランスによる評価および201Tlシンチグラフィとの併用が心筋症の重症度と相関する可能性が示された. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-meta-iodobenzylguanidine, Hypertrophic cardiomyopathy, Sympathetic nervous system, Single-photon emission computed tomography |
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| English |
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| Title | Evaluation of Hypertrophic Cardiomyopathy with 123I-Metaiodobenzylguanidine |
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| Subtitle | Original Articles |
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| Authors | Kenichi NAKAJIMA*, Hisashi BUNKO*, Junichi TAKI*, Masami SHIMIZU**, Ichiro NANBU*, Akira MURAMORI*, Ichiro MATSUNARI*, Kinichi HISADA* |
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| Authors(kana) | |
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| Organization | *Department of Nuclear Medicine, **The Second Department of Internal Medicine, Kanazawa University Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 27 |
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| Number | 1 |
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| Page | 33-38 |
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| Year/Month | 1990/1 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Single-photon emission computed tomography was performed in 29 patients with hypertrophic cardiomyopathy (HCM) using 123I-metaiodobenzylguanidine (MIBG) . Segmental myocardial uptake of MIBG and 201Tl was calculated in 21 patients with primary HCM without history of hypertension. Septal thickness was measured by echocardiography and the relationship to septal MIBG uptake was studied. Initial MIBG uptake and 201Tl uptake showed positive correlation with the septal thickness (R=0.581, p=0.0058 and R=0.677, p=0.0007) . When the septal MIBG uptake was divided by the corresponding 201Tl uptake (MIBG/Tl) , both the early and delayed MIBG/Tl showed negative correlation with the septal thickness (R=-0.485, p=0.0255 and R=-0.535, p=0.0125) . Significant positive correlation was observed between septal MIBG clearance and the thickness (R=0.510, p=0.0182) . In patients with severe septal hypertrophy (>20mm) , the MIBG clearance was significantly higher compared with less hypertrophic (<=20mm) group (13.4+-8.0%/hr vs. 3.2+-4.7%/hr, p=0.0028) . Thus, MIBG was useful for the evaluation of sympathetic innervation and activity in HCM. The MIBG clearance and uptake in conjunction with 201Tl study seemed to reflect the severity of hypertrophy in HCM. |
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| Practice | Clinical medicine |
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| Keywords | 123I-meta-iodobenzylguanidine, Hypertrophic cardiomyopathy, Sympathetic nervous system, Single-photon emission computed tomography |
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