| Japanese |
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| Title | 99mTc-Pyrophosphate心筋シンチグラフィにおいて, 異なる集積像を呈した心アミロイドーシスの3例 |
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| Subtitle | 症例報告 |
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| Authors | 竹崎雅之*, 石田良雄*, 両角隆一*, 谷明博*, 佐藤洋*, 堀正二*, 北畠顕*, 鎌田武信*, 依藤史郎**, 木村和文***, 中村幸夫****, 久住佳三****, 小塚隆弘**** |
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| Authors(kana) | |
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| Organization | *大阪大学医学部第一内科, **第二内科, ***大阪大学バイオメディカル教育センター, ****中央放射線部 |
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| Journal | 核医学 |
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| Volume | 26 |
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| Number | 12 |
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| Page | 1537-1543 |
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| Year/Month | 1989/12 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」心エコー図検査での心筋肥厚およびgranular sparkling appearance (GS) の存在と組織学的検索より心アミロイドーシスと診断された3例 (家族性アミロイドポリニューロパチー2例, 二次性アミロイドーシス1例) に, 99mTc-Pyrophosphate (99mTc-PYP) および201Tl心筋シンチグラフィを施行し, 各診断法の意義を検討した. 99mTc-PYPの心筋集積は, 家族性の2例で陽性であった. 二次性 (AA型アミロイド蛋白) の1例では, 高度な心筋アミロイド沈着が組織学的に確認されたが, 陰性であった. したがって, 99mTc-PYP心筋集積は, 心アミロイドーシスのなかでもアミロイド蛋白の種類により異なると考えられ, AA型蛋白の二次性の例で陰性を示すことは, 99mTc-PYPによる診断の限界を示すと考えられた. 一方, 201Tl像では, 限局性に高度なアミロイドの沈着が認められた家族性の1例でのみ欠損像が描出された. |
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| Practice | 臨床医学：一般 |
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| Keywords | Cardiac amyloidosis, Technetium-99m-pyrophosphate scintigraphy, Familial amyloid polyneuropathy, Secondary amyloidosis. |
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| English |
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| Title | Noninvasive Diagnosis of Cardiac Involvement by Technetium-99m-Pyrophosphate (Tc-99m PYP) Myocardial Scintigraphy in 2 Cases with Familial Amyloid Polyneuropathy and 1 Case with Secondary Amyloidosis |
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| Authors | Masayuki TAKEZAKI*, Yoshio ISHIDA*, Takakazu MOROZUMI*, Akihiro TANI*, Hiroshi SATO*, Masatsugu HORI*, Akira KITABATAKE*, Takenobu KAMADA*, Kazufumi KIMURA**, Takahiro KOZUKA***, 依藤史郎****, 中村幸夫***, 久住佳三*** |
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| Authors(kana) | |
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| Organization | *The First Department of Medicine, **Biomedical Research Center, ***Department of Radiology, Osaka University School of Medicine, ****大阪大学医学部第二内科 |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 26 |
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| Number | 12 |
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| Page | 1537-1543 |
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| Year/Month | 1989/12 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] To validate the significance of technetium-99m-pyrophosphate (Tc-99m PYP) myocardial scintigraphy in diagnosing cardiac amyloidosis, 2 patients with familial amyloid polyneuropathy (FAP) and 1 patient with amyloidosis secondary to chronic rheumatic arthritis were studied. All three patients had echocardiographic abnormalities, which were increased wall thickness of the interventricular septum and the left ventricular posterior wall, and granular sparkling appearance in the septum. In 2 patients with FAP, abnormal myocardial uptake of Tc-99m PYP was diffusely detected in Tc-99m PYP SPECT. In the remaining 1 patient with secondary amyloidosis, however, Tc-99m PYP SPECT showed no abnormality, although we had confirmed the presence of myocardial amyloid deposits (type AA amyloid protein) with high amount in the histological examination. Thus, these results indicate that Tc-99m PYP scintigraphy may have a limitation in detecting cardiac involvement in secondary amyloidosis although it is useful in FAP. |
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| Practice | Clinical medicine |
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| Keywords | Cardiac amyloidosis, Technetium-99m-pyrophosphate scintigraphy, Familial amyloid polyneuropathy, Secondary amyloidosis. |
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