| Japanese |
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| Title | 心筋の側鎖メチル脂肪酸摂取と血流の分離評価 |
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| Subtitle | 原著 |
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| Authors | 谷口充*, 分校久志*, 中嶋憲一*, 滝淳一*, 村守朗*, 松成一郎*, 南部一郎*, 四位例靖*, 利波紀久*, 久田欣一* |
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| Organization | *金沢大学医学部核医学科 |
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| Journal | 核医学 |
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| Volume | 26 |
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| Number | 12 |
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| Page | 1523-1530 |
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| Year/Month | 1989/12 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」I-125標識側鎖メチル脂肪酸 (BMIPP) とTl-201をラットに同時投与して心筋血流・代謝情報の分離評価を検討した. BMIPPの心筋集積率は静注後5-60分の間は3.1-3.6%ID/gであった. BMIPPのtarget to background ratioは心筋/肝比 (1.31) が比較的低かった. グルコース負荷群はBMIPPの心筋集積率 (1.94±0.36%ID/g) および心筋取り込み比 (g-BMIPP/Tl, 0.31±0.03) が対照群 (3.16±0.18%ID/g, 0.48±0.05) に比し有意に低下した (P<0.001) . 乳酸負荷群は他群に比し心筋血流量が有意に低下した. 心筋オートラジオグラムの定量的検討では, BMIPPの分布がTl-201に比し不均一で, 心内膜側でBMIPPの集積が低下する傾向にあった. BMIPPはTl-201の2核種イメージングによって心筋血流と脂肪酸代謝の分離評価が可能であり従来得られなかった新しい情報が得られる可能性が示唆された. |
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| Practice | 臨床医学：一般 |
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| Keywords | Radioiodinated-15- (p-iodophenyl) -3-R, S-methyl pentadecanoic acid (BMIPP) , Autoradiography, Myocardium, Glucose, Lctate, Tl-201. |
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| English |
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| Title | Separate Evaluation of Beta-Methyl Fatty Acid Uptake and Perfusion in Rat Myocardium |
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| Authors | Mitsuru TANIGUCHI, Hisashi BUNKOU, Kenichi NAKAJIMA, Junichi TAKI, Akira MURAMORI, Ichirou MATSUNARI, Ichirou NAMBU, Yasushi SHIIREI, Norihisa Tonami, Kinichi HISADA |
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| Authors(kana) | |
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| Organization | Department of Nuclear Medicine, Kanazawa University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 26 |
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| Number | 12 |
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| Page | 1523-1530 |
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| Year/Month | 1989/12 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] The kinetics and distribution of I-125 betamethyl iodophenyl pentadecanoic acid (BMIPP) in rat's heart were studied for separate evaluation of perfusion and metabolism. Tl-201 and BMIPP were simultaneously injected. The experimental groups consisted of control (C) , glucose (G) and sodium lactate loaded group (L) . In C, myocardial uptake at 5 minutes after BMIPP injection was 3.60%ID/g and remained constant up to 60 minutes. The myocardium/lung ratio (2.44) and the myocardium/muscle ratio (4.55) of BMIPP were almost equal to those of Tl-201. But myocardium/liver ratio was low (1.31) . In G, myocardial uptake of BMIPP (1.94+-0.36%ID/g) and g-BMIPP/Tl (0.31+-0.03) at 15 minutes after injection were significantly decreased (p<0.001) than those of C (3.16+-0.18%ID/g and 0.48+-0.05) . In L, myocardial perfusion was decreased and g-BMIPP/Tl (0.73+-0.14) was significantly higher (p<0.01) than those of C. Coefficient of variance of the density within a myocardium, and the ratio of inner to outer layer of myocardium (I/O ratio) were calculated from autoradiogram by videodensitometry. The myocardial distribution of BMIPP was more inhomogeneous, and the I/O ratio was lower than that of Tl-201, although these were not specific for metabolic interventions. In conclusion BMIPP is suitable for SPECT imaging and dual nuclide imaging by BMIPP and Tl-201 will provide informations about myocardial fatty acid metabolism and perfusion. |
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| Practice | Clinical medicine |
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| Keywords | Radioiodinated-15- (p-iodophenyl) -3-R, S-methyl pentadecanoic acid (BMIPP) , Autoradiography, Myocardium, Glucose, Lctate, Tl-201. |
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