| Japanese |
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| Title | 心プールシンチグラフィによる左室最大充満速度と左室弛緩速度の関連 |
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| Subtitle | 原著 |
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| Authors | 杉原洋樹*, 稲垣末次*, 中川達哉*, 片平敏雄*, 志賀浩治*, 窪田靖志*, 東秋弘*, 古川啓三*, 朝山純*, 勝目紘*, 中川雅夫* |
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| Organization | *京都府立医科大学第二内科 |
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| Journal | 核医学 |
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| Volume | 26 |
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| Number | 12 |
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| Page | 1493-1501 |
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| Year/Month | 1989/12 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」心電図同期心プールシンチグラフィより容易に算出される拡張早期左室最大充満速度 (PFR) が等容拡張期の左室弛緩速度を反映するか否かを後負荷増大時の影響を含め検討した. 虚血性心疾患および健常者16例を対象として, 心電図同期心プールシンチグラフィとカテ先マノメータによる左室圧測定を同時に施行した. 前者よりPFR (実測値, 一回拍出量, 瞬時および拡張末期容積補正) , 後者より左室圧下降脚を指数関数近似して得られる時定数Tを算出し, 左室弛緩速度の指標とした. コントロール時Tは実測値PFRとは相関しなかったが, 一回拍出量補正PFRと弱い負の相関を, 瞬時容積および拡張末期容積補正PFRとは比較的良好な負の相関を示した. アンジオテンシンII負荷によりTは延長し, 拡張末期容積補正PFRは減少し, 両者の変化は比較的よく対応した. 心電図同期心プールシンチグラフィより算出した瞬時または拡張末期容積補正のPFRは左室弛緩速度を比較的よく反映する有用な指標と考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Radionuclide ventriculography, Peak filling rate, Left ventricular relaxation rate. |
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| English |
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| Title | An Examination of Left Ventricular Peak Filling Rate and Ventricular Relaxation Rate by Simultaneous Acquisition of Radionuclide Ventriculography and Left Ventricular Pressure |
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| Authors | Hiroki SUGIHARA, Suetsugu INAGAKI, Tatsuya NAKAGAWA, Toshio KATAHIRA, Kouji SHIGA, Yasushi KUBOTA, Akihiro AZUMA, Keizo FURUKAWA, Jun ASAYAMA, Hiroshi KATSUME, Masao NAKAGAWA |
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| Organization | Second Department of Medicine, Kyoto Prefectural University of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 26 |
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| Number | 12 |
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| Page | 1493-1501 |
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| Year/Month | 1989/12 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] We investigated whether peak filling rate (PFR) obtained from ECG gated radionuclide ventriculography (RNV) reflects left ventricular (LV) relaxation rate or not. Five patients with angina pectoris, 5 patients with old myocardial infarction and 6 controls were studied by simultaneous acquisition of RNV and LV pressure. RNV was performed in modified left anterior oblique position before and during angiotensin II (A II) infusion to elevate their blood pressure about 25 mmHg (A-1) and 50 mmHg (A-2) . The data were acquired in a list mode and LV volume curves were reconstructed by forward and backward gating from the R wave of ECG. Actual PFR and corrected PFR by stroke volume (/SV) , by end diastolic volume (/EDV) , by instantaneous volume (/IV) were calculated from LV volume curve and its first differential curve. LV pressure was simultaneously measured by the catheter-tip micromanometer, and the time constant (T) of assumed exponential decline in LV pressure was calculated as index of LV relaxation rate. Although there was no correlation between actual PFR and T, corrected PFR (/EDV) and PFR (/IV) correlated with T. PFR (/EDV) decreased and T increased during A-1 and A-2. Decrease of PFR (/EDV) corresponded with increase of T. Thus, corrected PFR (/EDV) obtained from RNV reflects the rate of LV relaxation, and was considered to be an useful index to evaluate LV diastolic function. |
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| Practice | Clinical medicine |
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| Keywords | Radionuclide ventriculography, Peak filling rate, Left ventricular relaxation rate. |
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