| Japanese |
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| Title | SPECTによるTIAの検討 - 病態解析およびmisery perfusionの検出 - |
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| Subtitle | 原著 |
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| Authors | 外山宏*, 竹下元*, 竹内昭*, 江尻和隆*, 前田寿登*, 片田和廣*, 古賀佑彦*, 石山憲雄**, 神野哲夫** |
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| Organization | *藤田学園保健衛生大学医学部放射線科, **脳神経外科 |
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| Journal | 核医学 |
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| Volume | 26 |
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| Number | 12 |
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| Page | 1487-1492 |
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| Year/Month | 1989/12 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」TIAの患者42人｛A群 (23人:主幹部脳動脈の高度狭窄性病変を認めないもの) , B群 (19人:主幹部脳動脈の慢性的な閉塞症あるいは高度狭窄症) ｝および正常ボランティア9人についてSPECTにてrCBF, rCBVを求め, hemodynamic mechanismの観点からその成因について検討した. rCBFは133Xe, rCBVは99mTc-赤血球より求めた. 患側大脳半球のrCBF, rCBVを正常ボランティアの平均rCBF, 平均rCBVと比較検討した. A群の11人, B群の15人にrCBFの低下を認め, B群に多く認められた. その中でもrCBVの上昇も伴っていたのはA群では1例もなく, B群でも6例のみであった. 主な成因として, A群およびB群のrCBVの上昇がない例は微小血栓, B群の中でrCBVが上昇している例は脳血管不全が疑われた. B群の中でrCBFが低下しrCBVも上昇している症例はmisery perfusionと推定された. SPECTでのrCBFとrCBVの測定は, TIAの病態解析に有用であった. |
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| Practice | 臨床医学：一般 |
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| Keywords | Single photon emission computed tomography (SPECT) , Transient ischemic attack (TIA) , Regional cerebral blood flow (rCBF) , Regional cerebral blood volume (rCBV) , Misery perfusion. |
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| English |
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| Title | SPECT Measurement of Cerebral Hemodynamics in Transient Ischemic Attack Patients - Evaluation of Pathogenesis and Detection of Misery Perfusion - |
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| Subtitle | |
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| Authors | Hiroshi TOYAMA*, Gen TAKESHITA*, Akira TAKEUCHI*, Kazutaka EJIRI*, Hisato MAEDA*, Kazuhiro KATADA*, Sukehiko KOGA*, Norio ISHIYAMA**, Tetsuo KANNO** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, **Department of Neurosurgery, Fujita Health University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 26 |
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| Number | 12 |
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| Page | 1487-1492 |
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| Year/Month | 1989/12 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] To evaluate the cerebral hemodynamics and the pathogenesis by regional cerebral blood flow (rCBF) and regional cerebral blood volume (rCBV) , 42 transient ischemic attack (TIA) patients and 9 normal volunteers were studied using SPECT. We classified these patients into Group A (n=23: no occlusion or stenosis of the internal carotid or middle cerebral artery; non large vessel disease) and Group B (n=19: chronic occlusion or severe stenosis of the internal carotid or middle cerebral artery; large vessel disease) . We obtained rCBF with 133Xe inhalation and rCBV with 99mTc-red blood cells. Of 9 normal volunteers aged 43-70 yr (mean age 59.8+-8.3 yr) , the mean rCBF was 45.8+-5.1 (ml/100 g brain/min) , the mean rCBV was 4.0+-0.4 (ml/100 g brain) . The examination was done by comparing the values of the affected hemispheres of Group A and Group B patients with the mean rCBF and the mean rCBV of normal volunteers. Eleven out of Group A patients and 15 out of Group B patients showed decreased rCBF. But of those patients, no patients of Group A showed increased rCBV and 6 out of 19 Group B patients showed increased rCBV. Thromboembolic mechanism which is of Group A patients and Group B patients without increased rCBV, and hemodynamic mechanism which is of Group B patients with increased rCBV were considered as the main cause of TIA. Decreased rCBF and increased rCBV in Group B patients can be assumed as the misery perfusion as reported in PET studies. We conclude that SPECT measurement of not only rCBF but also rCBV on TIA patients is very significant to evaluate the pathogenesis and to detect the misery perfusion. |
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| Practice | Clinical medicine |
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| Keywords | Single photon emission computed tomography (SPECT) , Transient ischemic attack (TIA) , Regional cerebral blood flow (rCBF) , Regional cerebral blood volume (rCBV) , Misery perfusion. |
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