| Japanese |
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| Title | 123I-IMP SPECTによる脳動静脈奇形の手術前, 後の脳血液循環動態の評価 |
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| Subtitle | 原著 |
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| Authors | 外山宏*, 竹下元*, 竹内昭*, 江尻和隆*, 前田寿登*, 片田和廣*, 古賀佑彦*, 加藤庸子**, 阿部守**, 佐野公俊**, 神野哲夫** |
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| Organization | *藤田学園保健衛生大学医学部放射線科, **脳神経外科 |
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| Journal | 核医学 |
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| Volume | 26 |
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| Number | 12 |
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| Page | 1479-1486 |
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| Year/Month | 1989/12 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」脳動静脈奇形 (AVM) 6例の全摘出術前, 翌日, 7〜10日後の3回123I-IMP SPECTを行い, 手術前後の脳血流の変化について検討した. 装置はHEADTOME SET-031を用いた. 方法は123I-IMP 222 MBq (6 mCi) 静注後1フレーム/分にて10分間ダイナミックスキャンを行い, 続いてスタティックスキャンを行った. 術前のダイナミックイメージにて最初の1フレームでのみnidusの高集積を認め, 血液プールの反映と思われた. 術前のスタティックイメージにてnidusは著明な低血流となり, 周囲脳組織はstealによる低血流を認めた. 手術翌日には, 周囲脳組織において6例中4例に低血流の改善を認め, そのうちの2例にpostoperative hyperperfusion (NPPB) を認めた. また6例中2例に低血流の増悪を認め, 一時的な局所脳損傷と浮腫による影響が考えられた. 123I-IMP SPECTはAVM手術適応の判断, 合併症の予想, 手術前後の評価に有用であった. |
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| Practice | 臨床医学：一般 |
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| Keywords | Single photon emission computed tomography (SPECT) , Arteriovenous malformation (AVM) , Normal perfusion pressure breakthrough (NPPB) , N-isopropyl-p-[123I]-iodoamphetamine (123I-IMP) , Cerebral hemodynamics. |
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| English |
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| Title | Evaluation of Cerebral Hemodynamics by 123I-IMP in Cerebral AVMs before and after Operation by Using SPECT |
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| Authors | Hiroshi TOYAMA*, Gen TAKESHITA*, Akira TAKEUCHI*, Kazutaka EJIRI*, Hisato MAEDA*, Kazuhiro KATADA*, Sukehiko KOGA*, Yoko KATO**, Mamoru ABE**, Hirotoshi SANO**, Tetsuo KANNO** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, **Department of Neurosurgery, Fujita Health University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 26 |
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| Number | 12 |
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| Page | 1479-1486 |
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| Year/Month | 1989/12 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] To evaluate cerebral hemodynamics by N-isopropyl-p-[123I]-iodoamphetamine (123I-IMP) preoperative and postoperative (after 1 day, and after 7-10 days) regional cerebral blood flow scan, 6 arteriovenous malformations (AVMs) which performed total removal operations were studied by using a ring type SPECT "HEADTOME" . We performed the dynamic scan just after the intravenous injection of 222 MBq (6 mCi) of 123I-IMP, then the static scan 20 minutes after the intravenous injection. In preoperative dynamic scans of all cases, only the first frame image showed the increased activity on the nidus probably because of the blood pool. Preoperative static scans of all cases showed the remarkable decreased activity on the nidus, and decreased activity surrounding the nidus probably because of the peripheral steal phenomenon. In postoperative scan of the next day, 4 out of 6 cases showed the transient decreased peripheral steal, particularly 2 out of those 4 cases showed the transient hyperperfusion probably because of the normal perfusion pressure breakthrough (NPPB) . And, 2 out of 6 cases showed transient peripheral low perfusion on much larger area than those of the preoperative scans probably because of the focal brain damages and edemas. We conclude that 123I-IMP SPECT on AVM is very useful to decide the indication of the removal operation, and to estimate the postoperative risk, and to evaluate the preoperative and postoperative cerebral hemodynamic changes in the peripheral area of AVM. |
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| Practice | Clinical medicine |
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| Keywords | Single photon emission computed tomography (SPECT) , Arteriovenous malformation (AVM) , Normal perfusion pressure breakthrough (NPPB) , N-isopropyl-p-[123I]-iodoamphetamine (123I-IMP) , Cerebral hemodynamics. |
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