| Japanese |
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| Title | 間質性肺疾患におけるI-123IMP肺動態の検討 - 動態シンチグラムと局所クリアランス曲線による疾患活動性の評価 - |
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| Subtitle | 原著 |
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| Authors | 熊崎智司* |
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| Authors(kana) | |
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| Organization | *関東逓信病院呼吸器科 |
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| Journal | 核医学 |
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| Volume | 26 |
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| Number | 11 |
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| Page | 1417-1428 |
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| Year/Month | 1989/11 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 N-isopropyl-p-[123I]iodoamphetamine (I-123IMP) の肺動態シンチグラフィとその解析を間質性肺疾患症例に行い, 有用性を検討した. 両肺野に関心領域を設定し, その時間放射能曲線をmonoexponential curveに近似させて傾きk値を求めた. 間質性肺疾患では, 正常例に比較しk値は有意に低下していた. 肺機能検査値では, DLCO値とk値に良好な相関を認めた. I-123IMPの肺からのクリアランスには, 肺の毛細管血量の与える影響が大きいと思われる. I-123IMP肺クリアランスカーブの解析は, 従来の検査法では捉えられなかった非呼吸性肺機能の情報を得ることができ, 間質性肺疾患の活動性の指標として, 日常臨床での応用が可能であると考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | N-isopropyl-p-[I-123]-iodoamphetamine, Interstitial lung disease, Capillary blood volume, Non-respiratory pulmonary function, Endothelial cell injury |
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| English |
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| Title | A Study on the Intrapulmonary Kinetics of N-Isopropyl-p-[I-123]-lodoamphetamine in Patients with Interstitial Lung Diseases - Assessment of Disease Activity by Dynamic Scintigraphy and Regional Clearance Curve - |
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| Subtitle | Original Articles |
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| Authors | Satoshi KUMAZAKI |
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| Authors(kana) | |
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| Organization | Department of Respiratory Medicine, Kanto Teishi Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 26 |
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| Number | 11 |
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| Page | 1417-1428 |
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| Year/Month | 1989/11 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Aiming at clinical application of N-isopropyl- p-[I-123]-iodoamphetamine (I-123 IMP) to lung diseases intrapulmonary kinetics of I-123 IMP was studied. Dynamic lung scintigraphy was performed after intravenous injection of 3 MBq I-123 IMP in six normal volunteers and twenty patients with interstitial lung diseases. Simultaneously data were acquired in a data processor with 60-sec intervals over the period of 60 min. Time-activity curves of two areas of each lung field were obtained to calculate k values by monoexponential fitting method. In patients with interstitial lung diseases k values were significantly decreased (p<0.001) (0.995×10(-2)+-0.26×10(-2)) as compared with those (1.602×10(-2)+-0.24×10(-2)) in normal volunteers. For the assessment of capillary blood volume in the lung Tc-99m Sn colloids (SN) were given i.v. before I-123 IMP in 16 patients. There was a high correlation between regional uptake ratio of I-123 IMP and Tc-99m Sn colloids (SN) both at 1 min (n=64 ; r=0.91) and 25 min (n=64 ; r=0.93) after injection. The k values of IMP clearance curves were correlative to diffusing capacity at rest for CO (DLCO) (r=0.71, p<0.01) , vital capacity (r=0.53, P<0.05) and forced expiratory volume in 1 sec (r=0.58, p<0.05). These results suggest that the lung clearance of I-123 IMP reflect the severity of the endothelial cell injury which cause decrease in the capillary blood volume in interstitial lung diseases. Dynamic lung scintigraphy with I-123 IMP should prove useful for monitoring disease activity of interstitial lung diseases providing a new parameters to assess a non-respiratory lung function. |
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| Practice | Clinical medicine |
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| Keywords | N-isopropyl-p-[I-123]-iodoamphetamine, Interstitial lung disease, Capillary blood volume, Non-respiratory pulmonary function, Endothelial cell injury |
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