| Japanese |
|---|
| Title | 123I-IMP Single Photon Emission Computed Tomography (SPECT) によるParkinson病の臨床的検討 |
|---|
| Subtitle | 原著 |
|---|
| Authors | 林浩子*, 小田野幾雄*, 西原真美子*, 樋口正一*, 酒井邦夫*, 石川厚** |
|---|
| Authors(kana) | |
|---|
| Organization | *新潟大学医学部放射線医学教室, **脳研究所神経内科学教室 |
|---|
| Journal | 核医学 |
|---|
| Volume | 26 |
|---|
| Number | 11 |
|---|
| Page | 1405-1415 |
|---|
| Year/Month | 1989/11 |
|---|
| Article | 原著 |
|---|
| Publisher | 日本核医学会 |
|---|
| Abstract | 「要旨」 N-isopropyl-p-[123I]iodoamphetamine (123I-IMP) は初回循環で高率に脳組織にとりこまれ, その分布が局所脳血流量 (rCBF) を示す薬剤として使用されている. われわれはParkinson病 (PD) の病態を究明するため, PD患者20例, 正常者8例を対象に123I-IMPを用いたsingle photon emission computed tomography (SPECT) を施行し, 持続動脈血サンプリング法により, 脳の各領域のrCBFを算出した. さらにPD患者については, 年齢, stage, 罹病期間, 脳の萎縮, 臨床症状の5項目につき検討し, rCBFとの関係を分析した. 正常者と比較しPD患者では, 各領域のrCBFが全般的に低下しており, テント上の平均rCBF (global CBF) は21.8%の低下を示した. 脳血流分布パターンは, 小脳を除き, PDと正常者でほとんど同様であった. 基底核や頭頂葉のrCBFと運動障害度 (motor disability score : MDS) との間には有意な相関がみられた (それぞれp<0.05) . さらに, 頭頂葉のrCBFとakinesiaとの間にも有意な相関がみられた (p<0.02) . 小脳を除く各領域のrCBFと脳萎縮の間にはいずれも相関がみられた. 痴呆の程度と各領域のrCBFは無関係であった. 123I-IMPを用いたSPECT studyはPDの病態分析に有効であると考えられる. |
|---|
| Practice | 臨床医学：一般 |
|---|
| Keywords | Parkinson's disease, 123I-IMP, Regional cerebral blood flow (rCBF) , Dementia, SPECT |
|---|
| English |
|---|
| Title | Clinical Evaluation of Parkinson's Disease Using 123I-IMP SPECT |
|---|
| Subtitle | Original Articles |
|---|
| Authors | Hiroko HAYASHI*, Ikuo ODANO*, Mamiko NISHIHARA*, Shouichi HIGUCHI*, Kunio SAKAI*, Atsushi ISHIKAWA** |
|---|
| Authors(kana) | |
|---|
| Organization | *Department of Radiology, Niigata University School of Medicine, **Deparment of Neurology, Brain Research Institute, Niigata University |
|---|
| Journal | The Japanese Journal of nuclear medicine |
|---|
| Volume | 26 |
|---|
| Number | 11 |
|---|
| Page | 1405-1415 |
|---|
| Year/Month | 1989/11 |
|---|
| Article | Original article |
|---|
| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
|---|
| Abstract | [Summary] N-isopropyl-p[123I]iodoamphetamine (123I-IMP) SPECT and regional cerebral blood flow (rCBF) studies were performed in 20 patients with Parkinson's disease (PD) and 8 normal subjects. RCBF was measured by the arterial blood sampling method which used the microsphere model. We analized seven factors which might be related to the rCBF in PD, i.e., age, stage, duration of the disease, cerebral atrophy, severity of dementia, laterality of symptoms and motor disability score (MDS ; the degree of akinesia, rigidity, tremor, gait disturbance, freezing and pulsion sign) . Compared with normal subjects, global CBF (supratentorial mean rCBF) was reduced 21.8% in PD. In particular, rCBF in the basal ganglia and that of frontal cortex were reduced 25.3%, 24.8%, respectively. Distribution patterns of rCBF in PD were almost as same as those in normals except for cerebellum. The reduction of both rCBFs in the basal ganglia and parietal cortex significantly correlated with MDS (p<0.05, respectively) . Especially, akinesia was closely correlated to the reduction of rCBF in the parietal cortex (p<0.02) . Moreover, we observed a significant relationship between cerebral atrophy and reduction of rCBF in each region except for cerebellum. However, there was no significant correlation between the severity of dementia and reduction of rCBF, even in the frontal cortex or parietal cortex. These data show that the severity of dementia in PD may be connected with other factors except for rCBF. 123I-IMP SPECT study is a useful method for clinical evaluation of PD. |
|---|
| Practice | Clinical medicine |
|---|
| Keywords | Parkinson's disease, 123I-IMP, Regional cerebral blood flow (rCBF) , Dementia, SPECT |
|---|