| Japanese |
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| Title | Thallium-201 Single photon emission CTによる脳腫瘍の検討 |
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| Subtitle | 原著 |
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| Authors | 荒木有三*, 今尾幸則*, 平田俊文*, 安藤隆*, 坂井昇*, 山田弘* |
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| Organization | *岐阜大学医学部脳神経外科 |
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| Journal | 核医学 |
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| Volume | 26 |
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| Number | 11 |
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| Page | 1363-1369 |
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| Year/Month | 1989/11 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 201Tl-chloride (201Tl) を使用したSPECTを脳腫瘍28例に施行した. 201Tlの集積度は, 病巣と正常脳の相対カウント数との差を正常脳の相対カウント数で除したものをthallium index (TLI) として評価した. 神経膠腫については, 組織学的に悪性例, その再発例で大部分がTLIは高値を示した. 一方, 髄膜腫, 脳梗塞亜急性期, 放射線脳壊死などでも201Tl集積が認められ, 神経膠腫以外では201Tlは組織学的悪性度の指標とはならなかった. X線CTの造影剤増強効果が強い症例では, TLIも高値を示した. また, 対象例の病理組織学的検索において光学顕微鏡による一視野当たりの血管断面数とTLIは有意な正の相関を示した. 以上より201Tlの集積は血液脳関門の障害および血管数を反映するものと考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 201Tl-chloride, SPECT, Brain tumor, Radiation necrosis |
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| English |
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| Title | Thallium-201 Imaging of Brain Tumors Using Single Photon Emission CT |
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| Subtitle | Original Articles |
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| Authors | Yuzo ARAKI, Yukinori IMAO, Toshifumi HIRATA, Takashi ANDOH, Noboru SAKAI, Hiromu YAMADA |
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| Authors(kana) | |
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| Organization | Department of Neurosurgery, Gifu University of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 26 |
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| Number | 11 |
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| Page | 1363-1369 |
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| Year/Month | 1989/11 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Single photon emission CT using thallium-201 chloride, injected intravenously, was performed on 28 cases of cerebral lesions, among which were 16 gliomas, 2 meningiomas, 5 other brain tumors, 3 metastatic brain tumors and 2 cerebral radiation necroses. The degree of thallium-201 accumulation was evaluated by a new method called the thallium index (TLI) ; that is, TLI was expressed as (T-C)/C (T and C indicate relative counts in a pixel of a lesion and in non-affected normal brain tissue, respectively) . Thallium-201 accumulation occurred in 86% (24) of the evaluated cases. In general, there was a tendency in high-grade or recurrent gliomas, as well as in metastatic brain tumors for the TLI values to be high. Moreover, high TLI values were noticed in cases of meningioma, radiation necrosis of cerebellum and in cases involving subacute stages of cerebral infarction. It is particularly noteworthy that the meningioma TLI values were about two times higher than those of the glioblastomas. The CT contrast-enhancement of lesions was clearly correlated with the TLI values, and the relationship between the TLI values and the number of vessels observed microscopically in the specimen was statistically significant. From the above results, it was concluded that thallium-201 accumulation in lesions might be strongly influenced by the development of vascularity in lesions, and/or the interference with the blood brain barrier due to the tumor itself. However, this malignancy diagnostic method is probably limited to the diagnosis of glioma. |
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| Practice | Clinical medicine |
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| Keywords | 201Tl-chloride, SPECT, Brain tumor, Radiation necrosis |
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