| Japanese |
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| Title | N-Isopropyl-P-[123I]Iodoamphetamineを用いたSingle Photon Emission Computed Tomographyによる虚血性脳疾患の相対的局所脳血流分布解析 |
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| Subtitle | 原著 |
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| Authors | 諏訪邦彦*, 朝比奈正幸**, 柴崎尚***, 佐々木康人**** |
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| Organization | *原町赤十字病院内科, **放射線科, ***群馬大学医学部脳神経外科, ****核医学科 |
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| Journal | 核医学 |
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| Volume | 26 |
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| Number | 10 |
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| Page | 1311-1319 |
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| Year/Month | 1989/10 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 虚血性脳疾患における123I-IMPの半定量的測定法および再分布像の数量化の検討を行った. 症例は37歳から80歳までの男性29例, 女性16例でTIA14, RIND8, mild infarct9, severe infarct14例であった. 123I-IMP3mCiを静注し, 15分と3時間後に撮像した. 病変部IMP画像を後頭葉視覚領域のROIのカウントでnormalizationすることにより相対的に表示し半定量化を試み, これをRelative Perfusion Rate (RPR) とした. Infarct例のX線CT上の低吸収域の大きさが大きくなるとその中心部IMP imageのRPRは有意 (P<0.01) に低値を示した. 虚血性脳疾患の病変部のRPRはTIA 81.3±5.1% (M±SD) , RIND63.0±10.6%, mild infarct64.6±8.5%, およびservere infarct40.2±13.8%と重症度に並行した血流低下が示された. Late imageでの再集積率 (Redistribution Rate ; RR) をRPR (late image) / RPR (early image) で表すとTIA, RIND, mild infarct, severe infarctでおのおの1.18±0.08, 1.41±0.20, 1.28±0.15, 1.21±0.31となり, RINDで有意に高いことが認められた (P<0.01) . Early imageでのRPRとlate imageでのRRは虚血性脳疾患の診断および予後を知るための重要な指標であると思われる. |
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| Practice | 臨床医学：一般 |
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| Keywords | IMP, Single photon emission computed tomography, Ischemic cerebral disease, Relative cerebral perfusion |
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| English |
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| Title | Analysis of Relative Cerebral Perfusion in Ischemic Cerebral Diseases by Single Photon Emission Computed Tomography Using N-Isopropyl-p-[123I]Iodoamphetamine |
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| Subtitle | Original Articles |
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| Authors | Kunihiko SUWA*, Masayuki ASAHINA**, Takashi SHIBAZAKI***, Yasuhito SASAKI**** |
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| Authors(kana) | |
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| Organization | *Department of Internal Medicine, **Department of Radiology, Haramachi Red Cross Hospital, ***Department of Neurosurgery, ****Department of Nuclear Medicine, School of Medicine, Gunma University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 26 |
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| Number | 10 |
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| Page | 1311-1319 |
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| Year/Month | 1989/10 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Semiquantitative analysis of 123I-IMP SPECT enabled to evaluate relative regional cerebral perfusion and redistribution rates. Two parameters were calculated ; the relative perfusion rate (RPR) is the ratio of radioactivity on a localized lesion devided by radioactivity on the visual cortex, the redistribution rate (RR) is the ratio of RPR in late images at 3 hrs devided by that in early images at 15 min postinjection. Total of 45 patients with ischemic cerebral diseases were studied. There were 29 males and 16 females with the age ranging from 37 yr to 80 yr. The RPRs were 81.3+-5.1% in TIA (14 cases) , 63.6+-10.6% in RIND (8 cases) , 64.6+-8.5% in mild infarction (9 cases) and 40.2+-13.8% in severe infarction (14 cases) . RPR on the lesion of the severe infarction was extremely low compared to that of TIA, RIND and mild infarction. RPRs of lesions in the mild and severe infarction were reversely correlated to the size of LDA on X-ray CT (p<0.01) . RPR was well correlated to clinical status of ischemic diseases. The RRs were 118+-0.08in TIA, 1.41+-0.20 in RIND, 1.28+-0.15 in mild infarction and 1.21+-0.31 in severe infarction. The RR of RIND was significantly higher than those of other categorized groups (p<0.01) . The RR may prove useful as a parameter reflecting tissue viability in cerebral ischemic diseases. The present method is easy and practical way to assess the relative distribution of regional cerebral perfusion, which should be useful for the evaluation of ischemic cerebral diseases, particulary for the early differentiation between reversible and irreversible lesions. |
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| Practice | Clinical medicine |
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| Keywords | IMP, Single photon emission computed tomography, Ischemic cerebral disease, Relative cerebral perfusion |
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