| Japanese |
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| Title | 111In-標識抗ミオシンモノクローナル抗体-Fabイメージングの臨床応用 (第3報) - 99mTc-ピロリン酸イメージングとの対比検討 - |
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| Subtitle | 原著 |
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| Authors | 玉木長良*, 山田武彦**, 松森昭**, 藤田透*, 大谷弘*, 渡辺祐司*, 米倉義晴*, 遠藤啓吾*, 小西淳二*, 河合忠一** |
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| Authors(kana) | |
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| Organization | *京都大学医学部放射線核医学科, **第三内科 |
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| Journal | 核医学 |
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| Volume | 26 |
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| Number | 9 |
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| Page | 1199-1205 |
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| Year/Month | 1989/9 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」111In-抗ミオシン抗体 (AM) による心筋病変の検出能を99mTc-ピロリン酸 (PYP) と対比検討した. 心筋梗塞13例, 心筋炎3例の計16例に, PYPを静注3時間後にPYP像を撮像した後, AMを静注し48時間後にAM像を得, 両者を比較した. 心筋梗塞13例中AMで梗塞部位が陽性になったのは11例 (85%) で, PYPではその中のわずか3例 (23%) しか陽性描出されなかった. 両者で陽性となったのは発症から8日までの急性心筋梗塞の3例であったが, 発症1〜2週間の5例ではAMですべて陽性に描出されたのに対し, PYPでは1例のみしか陽性とならなかった. また発症2週間以後の6例では, AMは4例 (67%) で陽性であったが, PYPでは全例陰性であった. 一方, 心筋炎の3例では, AMがその2例で陽性像を呈したのに対し, PYPは陽性描出されなかった. 以上よりAMは急性期だけでなくPYPでもはや陰性化した亜急性期の心筋病変をも陽性描出できる優れた手法と考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Indium-111 antimyosin, Technetium-99m pyrophosphate, Myocardial infarction, Myocarditis |
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| English |
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| Title | Clinical Trial of 111In-Antimyosin Antibody Imaging : (3) Comparison with 99mTc-Pyrophosphate Imaging |
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| Subtitle | Original Articles |
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| Authors | Nagara TAMAKI*, Takehiko YAMADA**, Akira MATSUMORI**, Toru FUJITA*, Hiroshi OHTANI*, Yuji WATANABE*, Yoshiharu YONEKURA*, Keigo ENDO*, Junji KONISHI*, Chuichi KAWAI** |
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| Authors(kana) | |
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| Organization | *Department of Nuclear Medicine, **The Third Division, Department of Internal Medicine, Kyoto University Faculty of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 26 |
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| Number | 9 |
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| Page | 1199-1205 |
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| Year/Month | 1989/9 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Clinical value of 111In-antimyosin monoclonal antibody F ab (AM) was compared with 99mTc-pyrophosphate (PYP) in 13 patients with myocardial infarction and 3 patients with myocarditis. Following PYP injection, PYP imaging was performed 3 hours later. Immediately after PYP imaging, AM was administrated and AM images were obtained 48 hours later. Abnormal accumulation in the infarcted myocardium was observed in 11 patients (85%) on AM images but only in 3 patients (23%) on PYP images. All patients within 8 days after the onset of infarction showed abnormal uptake on both images. Of 5 patients with 1 to 2 weeks after the onset of infarction, abnormal uptake was observed in all of them on AM images but only in one of them on PYP imaging. Furthermore, of 6 patients with more than 2 weeks after the onset, AM imaging showed abnormal uptake in 4 (67%) but PYP imaging did not show abnormal uptake in any of them. Similarly. Of 3 patients with myocarditis, diffuse uptake in the myocardium was observed in 2 of them on AM images but none of them showed abnormal uptake on PYP images. We conclude that AM imaging is a useful means for identifying not only acute stages but also subacute stages of myocardial necrosis where PYP imaging did not show any abnormality. |
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| Practice | Clinical medicine |
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| Keywords | Indium-111 antimyosin, Technetium-99m pyrophosphate, Myocardial infarction, Myocarditis |
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