| Japanese |
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| Title | 移植腎におけるTc-99m-DTPAを用いたRadioisotope (RI) deconvolution analysisの有用性 |
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| Subtitle | 原著 |
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| Authors | 林郁子* |
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| Organization | *東邦大学医学部腎臓学研究室 |
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| Journal | 核医学 |
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| Volume | 26 |
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| Number | 9 |
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| Page | 1193-1197 |
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| Year/Month | 1989/9 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 腎移植患者50例から得たTc-99m-DTPAの179レノグラムにO'Reillyらの方法によりdeconvolution analysisを行い, MTTとH0値を求めるとともにその有用性を検討したところ, MTTとH0値を組み合わせることで各病態の特徴的所見がより明確となり, 診断の助けになると考えられた. 正常群は他群に比してH0値が高値で, MTTは2分前後に集中していた. 慢性拒絶反応群ではMTTは正常群と大差ないが, H0値は有意に低下していた. 急性拒絶反応群とATN群は正常群に比してMTTはほぼ同程度に延長していた. H0値は両群とも正常群に比して低下していたが, ATN群でより著明な低下を示し, 両者の鑑別の助けになると考えられた. また, 急性拒絶反応群では血清クレアチニン値がまだ軽度の上昇を示す時期からH0値は低値を示し, deconvolution analysisは急性拒絶反応の早期診断に有用であると考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Transplanted kidney, Deconvolution analysis, Tc-99m-DTPA, Acute rejection |
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| English |
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| Title | Usefulness of Radioisotope (RI) Deconvolution Analysis with Tc-99m-DTPA in Transplanted Kidney |
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| Subtitle | Original Articles |
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| Authors | Ikuko HAYASHI |
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| Authors(kana) | |
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| Organization | Department of Nephrology, Toho University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 26 |
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| Number | 9 |
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| Page | 1193-1197 |
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| Year/Month | 1989/9 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] In 50 renal transplant recipients, we performed radioisotope (RI) deconvolution analysis, as reported by O'Reilly, in 179 renograms from dynamic renal scanning with Tc-99m-DTPA and obtained MTT (mean transit time) and H0 (initial height) values. We found characteristic features of various graft conditions using the combination of MTT and H0. The mean H0 value was greater in normally functioning grafted kidneys than in kidneys with other states. The mean MTT in the normal group was about 2 min. In the acute rejection group, the mean H0 value was lower and the mean MTT was more prolonged compared with the normal group. In ATN group, the mean MTT was similar to that in the acute rejection group, whereas the mean H0 value was lower. In the chronic rejection group, the mean MTT was similar to that in the normal group, but the mean H0 value showed a lower one. The hydronephrosis group had an extremely prolonged MTT. This study indicated that the combination of H0 and MTT obtained from RI deconvolution analysis is a valuable means of understanding the condition of renal grafts. |
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| Practice | Clinical medicine |
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| Keywords | Transplanted kidney, Deconvolution analysis, Tc-99m-DTPA, Acute rejection |
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