| Japanese |
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| Title | N-isopropyl p-[I-123]iodoamphetamine SPECTによるアルツハイマー病患者の脳血流に関する研究 |
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| Subtitle | 原著 |
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| Authors | 百瀬敏光*, 西川潤一*, 小坂昇*, 大嶽達*, 渡辺俊明*, 吉川宏起*, 飯尾正宏* |
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| Organization | *東京大学医学部放射線医学教室 |
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| Journal | 核医学 |
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| Volume | 26 |
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| Number | 9 |
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| Page | 1177-1192 |
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| Year/Month | 1989/9 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 アルツ・ハイマー病18例, ピック病5例, その他の変性痴呆6例, 正常対照12例の計41例に対し, I-123IMPの静注と回転型ガンマカメラによる脳SPECTを施行し, 脳局所の放射活性と小脳との比 (R/CE ratio) および前頭葉と頭頂葉の放射活性比 (F/P ratio) を算出した. 痴呆例全例に大脳皮質連合野のR/CE ratioの低下がみられたが, X線CTまたはMRIでは萎縮以外明らかな局所病変は認められなかった. アルツノハイマー病群では正常群と比較し, 両側ローランド野と左視覚領を除く, すべての領域でR/CE ratioは有意に低下 (P<0.05) していたが, 分布パターンはある程度多様性がみられた. 一方, F/P ratioはアルツハイマー病群で, 正常群, その他の痴呆群に比し, 有意に高値 (P<0.01) であった. I-123IMP-SPECTは, X線CTやMRIで検出不可能な局所脳血流量の低下を検出でき, アルツハイマー病と他の変性痴呆症との鑑別診断に有用な情報を提供するものと思われる. |
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| Practice | 臨床医学：一般 |
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| Keywords | N-isopropyl p-[I-123]iodoamphetamine, Single photon emission computed tomography, Alzheimer's disease, Pick disease, Dementia of non-Alzheimer type |
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| English |
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| Title | N-Isopropyl I-123 p-Iodoamphetamine (IMP) Brain SPECT in Alzheimer's Disease |
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| Subtitle | Original Articles |
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| Authors | Toshimitsu MOMOSE, Junichi NlSHIKAWA, Noboru KOSAKA, Tohru OHTAKE, Toshiaki WATANABE, Kohki YOSHIKAWA, Masahiro IIO |
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| Authors(kana) | |
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| Organization | Department Of Radiology, Faculty of Medicine, University of Tokyo |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 26 |
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| Number | 9 |
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| Page | 1177-1192 |
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| Year/Month | 1989/9 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Eighteen patients with Alzheimer's disease (AD) , 5 patients with Pick disease (PD) , 6 patients with other types of degenerative dementia (O) and 12 age-matched normal control subjects (N) were studied using N-isopropyl p-[I-123]iodoamphetamine (I-123 IMP) with SPECT. Regional to cerebellar activity (R/CE) ratio and frontal to parietal (F/P) activity ratio were evaluated in each case. I-123 IMP-SPECT revealed focal abnormality in all cases in AD, PD, O group, while XCT and/or MRI were normal or showed cerebral atrophy without focal abnormal density or intensity. In AD group, R/CE ratio in all the regions except for bilateral Rolandic area and left primary visual cortex were significantly lower (p<0.05 or p<0.01) than that in N group, and F/P ratio were significantly higher (P<0.01) than that in P and O group. In conclusion, I-123 IMP-SPECT is useful to detect focal perfusion abnormality in dementia and may be of value in differentiating Alzheimer's disease from dementia of non-Alzheimer type. |
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| Practice | Clinical medicine |
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| Keywords | N-isopropyl p-[I-123]iodoamphetamine, Single photon emission computed tomography, Alzheimer's disease, Pick disease, Dementia of non-Alzheimer type |
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