| Japanese |
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| Title | 腎血管性高血圧症の治療 (PTAまたは外科的血行再建術) 前後における分腎機能測定の有用性 |
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| Subtitle | 原著 |
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| Authors | 油野民雄*, 高山輝彦*, 中嶋憲一*, 瀬戸幹人*, 利波紀久*, 久田欣一* |
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| Authors(kana) | |
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| Organization | *金沢大学医学部核医学教室 |
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| Journal | 核医学 |
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| Volume | 26 |
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| Number | 9 |
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| Page | 1161-1167 |
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| Year/Month | 1989/9 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 PTAまたは外科的手段による腎血行再建術が行われた腎血管性高血圧症12例を対象として, 治療前後にERPFおよびGFRの分腎クリアランス検査を施行し, 分腎クリアランス測定の有用性を検討した. 偏側腎動脈狭窄10例中7例, 両側腎動脈狭窄2例 (4側) 中2側腎では偏側腎動脈狭窄の1例を除き, 血圧や静脈血のレニン活性値の改善とともに分腎ERPF, GFR値の改善を認めた. その際, 治療前の腎機能低下が軽度な症例ほど, 治療後に機能が改善される可能性が高い結果が得られた. また治療前後でカプトプリル負荷検査が施行された2例で, 治療前の狭窄側の特異的GFR低下が治療後に消失した. さらに治療後の長期経過中, 腎動脈狭窄の再発とともに分腎機能の悪化が1例で見られた. 以上より分腎クリアランス測定は, 治療による機能改善の有無, 治療効果の判定および再発の予知に有用と思われた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Renovascular hypertension, Percutaneous transluminal angioplasty, Split renal function, Effective renal plasma flow, Glomerular filtration rate |
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| English |
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| Title | Assessment of Split Renal Function before and after Angioplasty or Bypass Grafting in the Patients with Renovascular Hypertension |
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| Subtitle | Original Articles |
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| Authors | Tamio ABURANO, Teruhiko TAKAYAMA, Kenichi NAKAJIMA, Mikito SETO, Norihisa TONAMI, Kinichi HISADA |
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| Authors(kana) | |
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| Organization | Department of Nuclear Medicine, Kanazawa University Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 26 |
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| Number | 9 |
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| Page | 1161-1167 |
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| Year/Month | 1989/9 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Two different methods to assess the change of split renal function following angioplasty or bypass grafting were studied in a total of 12 patients with renovascular hypertension. The studies were performed before and within seven days after the therapeutic intervention. Split effective renal plasma flow (ERPF) and glomerular filtration rate (GFR) after injections of I-131 hippuran and Tc-99m DTPA were measured using kidney counting corrected for depth and dose, described by Schlegel and Gates. In six of 10 patients with unilateral renal artery stenosis and in two patients with bilateral renal artery stenoses (two of 4 affected kidneys) , the split renal function was improved after the therapeutic intervention, in accordance with the drop in blood pressure and the reduction of plasma renin activity. The improvement in ERPF and GFR was more likely in the patients without severely reduced renal function. In such patients, the improvement in ERPF was more pronounced than that in GFR. And in two patients with functional improvement, the Captopril-induced reduction of split GFR in the affected kidney was disappeared after the intervention. Moreover, in the long-term follow-up of three patients with functional improvement, one patient showed the deterioration of split renal function suggesting the relapse of renal artery stenosis. These results suggest that the combined studies of split ERPF and GFR determinations can be useful to evaluate the therapeutic effect as well as the presence or absence of functional improvement after the intervention. |
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| Practice | Clinical medicine |
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| Keywords | Renovascular hypertension, Percutaneous transluminal angioplasty, Split renal function, Effective renal plasma flow, Glomerular filtration rate |
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