| Japanese |
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| Title | 胃癌におけるペプシノーゲンI, II測定の意義 |
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| Subtitle | 原著 |
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| Authors | 木村良子*, 藤井崇*, 濱本研*, 宮川直子*, 津田孝治*, 棚田修二*, 飯尾篤* |
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| Authors(kana) | |
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| Organization | *愛媛大学医学部放射線科 |
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| Journal | 核医学 |
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| Volume | 26 |
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| Number | 9 |
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| Page | 1127-1133 |
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| Year/Month | 1989/9 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 胃液中に分泌される蛋白消化酵素ペプシンの2種の不活性前駆体ペプシノーゲン (以下PG-I, PG-II) の血清測定の, 胃癌における臨床的検討を行った. 正常人において95%の人は, PG-Iは26.5ng/ml以上に, PG-IIは4.3ng/ml以上に, PG-I/PG-IIは2.1以上に分布したが, 胃癌患者においては, PG-IとPG-I/PG-II比の低下傾向が見られ, 36.8%がPG-I<26.5ng/mlであり, 25.5%がPG-I/PG-II<2.1であった. さらに, PG-IとPG-I/PG-II比の組み合わせにより, 胃癌患者の約55%を検出し得るものと考えられた. しかし, 40歳以上の正常人の陽性率も高く, 胃癌全体としては有用性に劣ると考えられた. また, X線間接撮影において見逃しやすい硬癌や胃体上部の癌に比較的高い陽性率を認め, 胃癌発見の補助的手段となりうることが示唆された. また, 一部の症例では, 再発の発見に有用となる可能性が示唆された. |
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| Practice | 臨床医学：一般 |
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| Keywords | IRMA, Pepsinogen, Gastric cancer, Diagnosis |
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| English |
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| Title | Evaluation of Serum Pepsinogen I and II of Patients with Gastric Cancer |
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| Subtitle | Original Articles |
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| Authors | Yoshiko KIMURA, Takashi FUJII, Ken HAMAMOTO, Naoko MIYAGAWA, Kohji TSUDA, Shuji TANADA, Atsushi IIO |
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| Authors(kana) | |
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| Organization | Department of Radiology, Ehime University Medical School |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 26 |
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| Number | 9 |
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| Page | 1127-1133 |
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| Year/Month | 1989/9 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Serum pepsinogen levels were examined by immunoradiometric assay method for evaluating its clinical usefulness in gastric cancer. In patients with gastric cancer, serum PG-I tended to decrease but PG-II stayed normal level, resulting in low PG-1/PG-II ratio. Combination of PG-I and PG-I/PG-II discriminated 53.7% of gastric cancer, 70.6% of scirrhous type gastric cancer, and 66.7-100% of those arisen in the upper portion of the stomach, but 13.7% of normal subjects. As the aged normal subjects tended to show decreased PG-I/PG-II ratio (about 30% of the normal subjects aged over 40 years were discriminated as abnormal) , the usefulness for detection of gastric cancer seems to be limited, but some types of gastric cancer such as scirrhous type or one arisen in the upper portion may be discriminated by this method. It is also suggested that this method may detect the recurrence of the cancer in some patients. |
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| Practice | Clinical medicine |
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| Keywords | IRMA, Pepsinogen, Gastric cancer, Diagnosis |
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