| Japanese |
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| Title | Tc-99m DTPAおよびI-131 Hippuranによる分腎機能の評価に関する実験的検討 - 第二報 : 一過性腎静脈閉塞について - |
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| Subtitle | 原著 |
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| Authors | 高山輝彦*, 油野民雄**, 道岸隆敏**, 秀毛範至**, 絹谷清剛**, 瀬戸幹人**, 利波紀久**, 久田欣一** |
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| Authors(kana) | |
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| Organization | *金沢大学医療技術短期大学部診療放射線技術学科, **金沢大学医学部核医学教室 |
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| Journal | 核医学 |
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| Volume | 26 |
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| Number | 9 |
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| Page | 1121-1126 |
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| Year/Month | 1989/9 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 成熟雄ラットの左腎静脈をクランプを用い30分間閉塞した. その後30分, 3時間, 6時間, 2日, 7日に両大腿静脈よりTc-99m DTPA 7 μCi, I-131 Hippuran 3 μCiを注入し, 5, 10, 15, 20, 30分後に尾静脈より採血して血中クリアランス値を求めた. 採血終了後ただちに屠殺し, 両腎, 膀胱を摘出し, カウント数を測定した. 一過性腎静脈閉塞の場合, 解除後30分から6時間にわたりERPF, GFRは閉塞側でともに低下の傾向を示し, 30分と6時間のERPFについて有意差が認められたが, FFについて有意差は認めなかった. したがって分腎機能の評価にはERPF, GFR物質の両方による検討よりもどちらか一方による検討で十分と考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Tc-99m DTPA, I-131 Hippuran, Renal vein, Split renal function, Filtration fraction |
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| English |
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| Title | The Evaluation of Split Renal Function in the Experimentally Induced Transient Renal Vein Obstruction |
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| Subtitle | Original Articles |
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| Authors | Teruhiko TAKAYAMA*, Tamio ABURANO**, Takatoshi MlCHIGISHI**, Noriyuki SYUKE**, Seigo KINUYA**, Mikito SETO**, Norihisa TONAMI**, Kinichi HISADA** |
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| Authors(kana) | |
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| Organization | *The School of Allied Medical Professions, Kanazawa University, **Department of Nuclear Medicine, Kanazawa University Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 26 |
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| Number | 9 |
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| Page | 1121-1126 |
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| Year/Month | 1989/9 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] The split renal function was measured in order to evaluate the alteration of renal function secondary from transient renal vein obstruction. Three microcuries of I-131 Hippuran and 7 μCi of Tc-99m DTPA were injected into the femoral vein of adult male rats 30 min, 3hr, 6hr, 2days and 1 week after the renal vein obstruction for 30 min. Blood samples were taken from the tail vein 5, 10, 15, 20 and 30 min after injection. Immediately after taking blood sample at 30 min, both kidneys and urinary bladder with ureters were taken. The radioactivities of Tc-99m and I-131 of these samples were measured respectively using a well type scintillation counter at the energy ranges of 140 KeV+-25% and 360 KeV+-25%. In the obstructed side, the blood clearances of I-131 Hippuran (ERPF) and Tc-99m DTPA (GFR) were decreased at 30 min and 6 hr after the release of left renal vein obstruction. Therefore the filtration fraction was not significantly changed. In conclusion, the single study using either Tc-99m DTPA or I-131 Hippuran may be enough to evaluate the alteration of split renal function in a model of renal vein obstruction, although the combined study using both agents is more preferable. |
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| Practice | Clinical medicine |
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| Keywords | Tc-99m DTPA, I-131 Hippuran, Renal vein, Split renal function, Filtration fraction |
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