| Japanese |
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| Title | 血液透析患者の骨動態シンチグラフィの定量的検査方法 - 因子分析による検討 - |
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| Subtitle | ≪原著≫ |
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| Authors | 小泉義子*, 岡村光英*, 福田照男*, 井上佑一*, 大村昌弘*, 池田穂積*, 波多信*, 小田淳郎*, 越智宏暢*, 小野山靖人*, 細羽実**, 和迩秀信** |
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| Authors(kana) | |
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| Organization | *大阪市立大学医学部附属病院放射線科, **(株)島津製作所医用機器研究所 |
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| Journal | 核医学 |
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| Volume | 26 |
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| Number | 7 |
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| Page | 829-834 |
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| Year/Month | 1989/7 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」二次性副甲状腺機能亢進症を呈する腎不全患者の骨変化の定量的検査法として, 骨シンチearly phaseに因子分析を応用した. 方法はTc-99m-MDP 14.8 MBq/kgを肘静脈より急速注入し, 20分間頭部について情報を収集した(1フレーム30秒, 64×64マトリックス). 解析は9ポイントスムージングを行った後, 頭部に関心領域を設定し, 因子分析を施行した. その結果, 骨成分と血流成分が明瞭に抽出された. この結果を定量化するために次のような2つの指標を設定した. つまり頭部の全RNカウントと因子分析により得られた寄与率との積(骨集積計数: Bu)と, 機能成分を表す曲線から得られた2分値と20分値との比(Br)である. これらの指標は, 正常者と腎不全患者とでは, 明らかに異なり, 後者のBuは高値を, Brは低値を示した. 骨変化の定量的検査法として, 骨シンチ因子分析の有用性が示唆された. |
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| Practice | 臨床医学：一般 |
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| Keywords | Factor analysis, Renal osteodystrophy, Bone scintigraphy, Secondary hyperparathyroidism. |
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| English |
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| Title | Factor Analysis of Bone Mineral Dynamics in Patients with Renal Osteodystrophy |
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| Subtitle | - Original Articles - |
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| Authors | Yoshiko KOIZUMI*, Terue OKAMURA*, Teruo FUKUDA*, Yuichi INOUE*, Masahiro OOMURA*, Hozumi IKEDA*, Makoto HATA*, Junrou ODA*, Hironobu OCHI*, Yasuto ONOYAMA*, Minoru HOSOBA**, Hidenobu WANI** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, Osaka City University, Medical School, **Medical Technology Research Laboratory, Shimadzu Corporation |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 26 |
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| Number | 7 |
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| Page | 829-834 |
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| Year/Month | 1989/7 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Remarkably high accumulation of Tc-99m-MDP is seen in the skull on bone scintigraphy of patients with renal osteodystrophy (ROD), especially with secondary hyperparathyroidism. For the quantitative evaluation, the Factor Analysis (FA) was used for the early phase of bone scan. Tc-99m-MDP (14.8 MBq/body weight kg) was injected as a bolus through the medial antecubital vein. Dynamic acquisition of 40×30 sec frames were performed in a 64×64 matrix. For pre-processing, nine points smoothing was carried out, and then the region of interest was set on the frontal image of the head for the FA. The FA was performed with an 8×8 sampling corresponding to 64 dixels from 4,096 dixels. Bone factor was clearly extracted by the FA. Then, two original parameters were calculated. One is the bone radionuclide uptake counts (Bu) which is the product of the total radionuclide counts of skull and the contribution ratio, the other is the uptake ratio (Br) derived by the time activity curve (physiological component) of the FA. These parameters of ROD were significantly different compared to those of controls. The FA seems to be useful in quantitative evaluation of bone mineral dynamics. |
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| Practice | Clinical medicine |
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| Keywords | Factor analysis, Renal osteodystrophy, Bone scintigraphy, Secondary hyperparathyroidism. |
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