Japanese
Title虚血性脳疾患患者の99mTc-hexamethyl propyleneamine oximeによるSingle Photon Emission Computed Tomography (SPECT) : N-isopropyl-p-[123I]-iodoamphetamineおよび99mTc-DTPA SPECTとの比較
Subtitle≪原著≫
Authors小野志磨人*, 福永仁夫*, 大塚信昭*, 永井清久*, 森田浩一*, 三村浩朗*, 柳元真一*, 友光達志*, 小西吉裕**, 安田雄**, 寺尾章**, 渡辺明良***, 石井鐐二***, 中北和夫****, 小浜啓次****, 森田陸司*
Authors(kana)
Organization*川崎医科大学核医学科, **神経内科, ***脳外科, ****救急部
Journal核医学
Volume26
Number7
Page811-820
Year/Month1989/7
Article原著
Publisher日本核医学会
Abstract「要旨」脳虚血部位の診断および病態把握のために, 99mTc-PAO SPECTを虚血性脳疾患患者42例に行い, 123I-IMPおよび99mTc-DTPA SPECTとX線CTの所見を比較検討した. なお, 99mTc-PAOおよび123I-IMP SPECTによる病変部の検出能の評価には, 脳虚血部と対照正常部のカウント比(I/N)を用い, I/N比が0.95以下を集積低下とした. 99mTc-PAO SPECTによる脳虚血部位の検出率は80%であり, X線CTによるLDAの検出率(60%)よりも高率であったが, 特に発症後早期の症例で有用であった. 他方, 123I-IMP SPECTの検出能(88%)は最もすぐれており, I/N比も99mTc-PAOに比して小であった. 123I-IMP SPECTの後期像では30%に脳虚血部の再分布が観察されたのに対し, 99mTc-PAO SPECTの後期像では1例もみられなかった. 99mTc-DTPAの脳実質内への集積は14例中6例(43%)にみられたが, うち2例では同様に99mTc-PAOの脳虚血部への集積を示し, これらの症例ではBBB破綻の関与が示唆された. このように, 99mTc-PAO SPECTは虚血性疾患の臨床に有用な方法であると思われた.
Practice臨床医学：一般
Keywords99mTc-PAO, SPECT, Ischemic cerebral diseases, 123I-IMP, 99mTc-DTPA.
English
TitleSingle Photon Emission Computed Tomography (SPECT) Using 99mTc-Hexamethyl Propyleneamine Oxime in Patients with Ischemic Cerebral Diseases : Comparative Study of N-Isopropyl-p-[123I]-Iodoamphetamine and 99mTC-DTPA SPECT
Subtitle- Original Articles -
AuthorsShimato ONO*, Masao FUKUNAGA*, Nobuaki OTSUKA*, Kiyohisa NAGAI*, Koichi MORITA*, Hiroaki MIMURA*, Shinichi YANAGIMOTO*, Tatsushi TOMOMITSU*, Yoshihiro KONISHI**, Takeshi YASUDA**, Akira TERAO**, Akira WATANABE***, Ryoji ISHII***, Kazuo NAKAKITA****, Akitsugu KOHAMA****, Rikushi MORITA*
Authors(kana)
Organization*Department of Nuclear Medicine, **Department of Neurology, ***Department of Neurosurgery, ***Department of Emergency Medicine, Kawasaki Medical School
JournalThe Japanese Journal of nuclear medicine
Volume26
Number7
Page811-820
Year/Month1989/7
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary] In order to confirm the diagnosis and clarify the pathophysiology in the ischemic lesions in brain, 99mTc-PAO SPECT was performed in 42 patients with ischemic cerebral diseases, and the findings on 99mTc-PAO SPECT were compared with those on 123I-IMP or 99mTc-DTPA SPECT, and on X-CT. Furthermore, count ratio of ischemic lesion to normal contralateral region (I/N) was used for the evaluation of the detectability in the lesions on 99mTc-PAO or 123I-IMP SPECT, and less than 0.95 of I/N ratio was defined as the decreased accumulation. The detectability of ischemic lesion in brain with 99mTc-PAO SPECT was 80%, which was superior to that (60%) of LDA on X-CT. Especially, 99mTc-PAO SPECT was useful in cases which were examined early after the onset of the attack. On the other hand, 123I-IMP SPECT showed the best result (88%) in the detectability, and furthermore I/N ratio on 123I-IMP SPECT was lower than that on 99mTc-PAO SPECT. In the delayed phase on 123I-IMP SPECT the redistribution was observed in 30%, while on 99mTc-PAO SPECT it was done in none of them. The accumulation of 99mTc-DTPA in brain was found in 6 of 14 cases (43%), and 2 cases among them also showed the accumulation of 99mTc-PAO in the ischemic lesion. In such cases the destruction of BBB might be considered as the cause of the accumulation of 99mTc-PAO. Thus, 99mTc-PAO SPECT was thought to be useful method in clinical studies of the ischemic cerebral diseases.
PracticeClinical medicine
Keywords99mTc-PAO, SPECT, Ischemic cerebral diseases, 123I-IMP, 99mTc-DTPA.

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