| Japanese |
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| Title | 18F-fluorodeoxyglucose PETによる肝癌治療効果判定 |
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| Subtitle | ≪研究速報≫ |
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| Authors | 岡住慎一*, 榎本和夫*, 尾崎正彦*, 山本宏*, 吉田雅博*, 阿部恭久*, 高山亘*, 山田滋*, 磯野可一*, 今関恵子**, 吉川京燦**, 有水昇**, 伊藤裕***, 植松貞夫***, 竜崇正**** |
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| Authors(kana) | |
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| Organization | *千葉大学医学部第二外科, **放射線科, ***放射線部, ****千葉県がんセンター消化器科 |
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| Journal | 核医学 |
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| Volume | 26 |
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| Number | 6 |
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| Page | 793-797 |
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| Year/Month | 1989/6 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」原発性および転移性肝癌症例9例に対して, 18FDG静注法によるdynamic-PET studyを施行し, 腫瘍糖代謝の評価を行い, 肝癌治療効果判定における有用性について検討した. 全例に18FDGの集積を認め, Patlak's plotの応用により求めた糖代謝率係数(C値)を用いて比較すると, 0.016〜0.054の分布を示し, 各腫瘍ごとの糖代謝状態の較差が認められた. また, 治療前後の比較および切除標本の病理組織との対比より, C値は肝腫瘍のviabilityを反映していると考えられ, C値を指標として, 定量的かつ段階的な治療効果判定が可能と考えられた. また, lipiodolの沈着した腫瘍等, 他画像診断にてviabilityの評価の困難な症例に対しても有用であると考えられた. 「I. はじめに」18F-fluorodeoxyglucose (以下18FDG)は, glucoseのアナログで, 脳局所糖代謝率をPositron emission tomography (以下PET)により求める時に使用するトレーサーであり, また, 悪性腫瘍にも集積することが報告されている. |
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| Practice | 臨床医学：一般 |
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| Keywords | 18FDG, Positron emission tomography, Liver tumor. |
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| English |
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| Title | Evaluation of the Effect of Treatment for Patients with Liver Tumors Using 18F-fluorodeoxyglucose PET |
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| Subtitle | - Rapid Communication - |
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| Authors | Shinichi OKAZUMI*, Kazuo ENOMOTO*, Masahiko OZAKI*, Hiroshi YAMAMOTO*, Masahiro YOSHIDA*, Yasuhisa ABE*, Wataru TAKAYAMA*, Shigeru YAMADA*, Kaichi ISONO*, Keiko IMAZEKI**, Kyosan YOSHIKAWA**, Noboru ARIMIZU**, Yutaka ITO***, Sadao UEMATSU***, Munemasa RYU**** |
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| Authors(kana) | |
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| Organization | *Second Department of Surgery, **Department of Rodiology, ***Division of Radiology, Chiba University School of Medicine, ****Chiba Cancer Center |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 26 |
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| Number | 6 |
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| Page | 793-797 |
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| Year/Month | 1989/6 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] To evaluate the glucose metabolism in the liver tumor, 18FDG PET (Positron Emission Tomography) was performed in 9 patients with primary and metastatic liver tumors. And usefulness of 18FDG PET in clarifying the effect of treatment on liver tumor was examined. Glucose metabolism of tumor was showed in terms of the coefficient 'C' calculated by Patlak's plot. Each tumor's coefficient 'C' was 0.016-0.054 and it decreased after treatment. Compared with pathological findings, the coefficient 'C' of necrose part of tumor was 0.004 and fibrous change after irradiation was 0.007. It suggested that coefficient 'C'reflected activity of tumor and it was a useful index to know viability of tumors in the treatment for patients with liver tumors. |
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| Practice | Clinical medicine |
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| Keywords | 18FDG, Positron emission tomography, Liver tumor. |
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