| Japanese |
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| Title | 核医学手法による急性心筋梗塞症の治療効果の評価 - ウロキナーゼ静脈内投与法の検討とPTCR + PTCA療法との比較 - |
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| Subtitle | ≪原著≫ |
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| Authors | 山崎純一*, 河村康明*, 奥住一雄*, 森下健*, 大沢秀文**, 矢部喜正**, 斉藤徹***, 上嶋権兵衛*** |
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| Authors(kana) | |
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| Organization | *東邦大学医学部内科学第一講座, **循環器診断センター, ***救命救急センター |
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| Journal | 核医学 |
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| Volume | 26 |
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| Number | 6 |
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| Page | 743-752 |
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| Year/Month | 1989/6 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」急性心筋梗塞症(AMI)に対するウロキナーゼ静脈内投与法(UK法)による治療効果を検討するとともにPTCR + PTCAによる治療効果の結果と比較した. 対象はAMI 108例で急性期に核医学検査を施行しLVEF, Tl-defect ratio (Tl-DR)を算出した. UK法ではUK 120万単位投与群におけるTl-DRは1.63±0.8でUK 96万単位投与群の2.4±1.33と比較し低値を示したが両群ともコントロール群の35±2.5に比し良好な治療効果が得られた. AMI発症6時間以内にUKの投与された群はLVEF (44.5±11.2%), Tl-DR (1.68±0.82)と良好な結果が得られた. UK群はPTCR + PTCA群と比較し, LVEF (42.3±11.3 vs. 38.1±7.4), Tl-DR (2.10±1.19 vs. 2.09±0.62)とも後者に劣らない良好な結果が得られた, UK群, PTCR + PTCA群ともPeak-CPK値の上昇, LVEFの低下に比しTl-DRは良好に保たれており急性期のStunned myocardiumの存在が示唆された. 以上よりUK法はAMIに対し有用な治療であると結論された. |
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| Practice | 臨床医学：一般 |
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| Keywords | Urokinase, Intravenous thrombolysis, PTCR, PTCA, Thallium-201 myocardial scintigraphy. |
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| English |
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| Title | The Evaluation of the Therapeutic Effect on Acute Myocardial Infarction by Radioisotope Method - Assessment of the Intravenous Injection of Urokinase and Comparison With the Results of PTCR + PTCA - |
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| Subtitle | - Original Articles - |
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| Authors | Junichi YAMAZAKI*, Yasuaki KAWAMURA*, Ichio OKUZUMI*, Takeshi MORISHITA*, Hidefumi OHSAWA**, Yoshimasa YABE**, Toru SAITO***, Gonbei KAMISHIMA*** |
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| Authors(kana) | |
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| Organization | *First Department of Internal Medicine, **Cardiovascular Laboratory Center, ***ICU, Toho University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 26 |
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| Number | 6 |
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| Page | 743-752 |
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| Year/Month | 1989/6 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] The therapeutic effect of intravenous injection of Urokinase (UK method) on acute myocardial infarction (AMI) was studied and compared with the results of the therapeutic effect of PTCR + PTCA. The subjects comprise 108 cases with AMI, and a radioisotope examination was performed in the acute stage to calculate LVEF and Tl-defect ratio (Tl-DR). Measured by the UK method, Tl-DR in the group given 1.2×106 units of UK was 1.63 +- 0.8, which was lower than the 2.4 +- 1.33 for the group given 9.6×105 unit of UK, whereas a favorable therapeutic effect was obtained in both groups compared to 3.5 +- 2.5 in the control group. In the group given UK within 6 hours after the onset of AMI, favorable results were obtained for LVEF (44.5 +- 11.2%) and Tl-DR (1.68 +- 0.82). The UK group showed as better results as the PTCR + PTCA group for LVEF (42.3 +- 11.3 vs.38.1 +- 7.4) and Tl-DR (2.10 +- 1.19 vs.2.09 +- 0.62). In both the UK and PTCR + PTCA groups, Tl-DR was well maintained despite an increase in the peak CPK and a decrease in LVEF, and, therefore, the conservation of stunned myocardium in the acute stage was suggested. From the above, it was concluded that the UK method is useful for treating AMI. |
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| Practice | Clinical medicine |
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| Keywords | Urokinase, Intravenous thrombolysis, PTCR, PTCA, Thallium-201 myocardial scintigraphy. |
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