| Japanese |
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| Title | 111In-標識抗ミオシンモノクローナル抗体-F abイメージングの臨床応用 (第2報) - 心筋梗塞・心筋炎の画像診断 - |
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| Subtitle | ≪原著≫ |
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| Authors | 松森昭*, 山田武彦*, 玉木長良**, 岡田幾太郎*, 富永真琴*, 河合忠一*, 渡辺祐司**, 米倉義晴**, 遠藤啓吾**, 小西淳二**, 吉田章***, 田巻俊一**** |
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| Authors(kana) | |
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| Organization | *京都大学医学部第三内科学教室, **核医学教室, ***三菱京都病院, ****武田病院 |
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| Journal | 核医学 |
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| Volume | 26 |
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| Number | 6 |
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| Page | 723-731 |
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| Year/Month | 1989/6 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」心筋細胞壊死巣描出を目的として, 111In-標識抗ミオシンモノクローナル抗体-F abによる心筋シンチグラフィの臨床応用を検討した. 心筋梗塞35例では梗塞部位に一致して陽性像がみられ発症16日以内では, 27例中26例(96%)で陽性像が得られたがそのうち大部分では血清酵素値はすでに正常化していた. 発症1〜9か月後にも陽性像が認められたが梗塞巣の大きいものや, 左室壁運動異常のみられるものが陽性を呈する傾向にあった. 心筋生検にて急性心筋炎と確定した2例では発症2週間後で血清酵素値は正常化し急性炎症反応の消退した時期にびまん性の取り込みを認めた. 111In-抗ミオシンモノクローナル抗体によるシンチグラフィは心筋梗塞, 心筋炎の急性期のみならず亜急性期における非侵襲的診断法としてきわめて有望な検査法であると考えられる. |
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| Practice | 臨床医学：一般 |
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| Keywords | Antimyosin, Monoclonal antibody, Imaging, Myocarditis, Myocardial infarction. |
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| English |
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| Title | Clinical Trial of 111In-Antimyosin Antibody Imaging : (2) Imaging of Myocardial Infarction and Myocarditis |
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| Subtitle | - Original Articles - |
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| Authors | Akira MATSUMORI*, Takehiko YAMADA*, Nagara TAMAKI**, Ikutaro OKADA*, Makoto TOMINAGA*, Chuichi KAWAI*, Yuji WATANABE**, Yoshiharu YONEKURA**, Keigo ENDO**, Junji KONISHI**, Akira YOSHIDA, Shunichi TAMAKI**** |
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| Authors(kana) | |
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| Organization | *The Third Division, Department of Internal Medicine, **Department of Nuclear Medicine, Faculty of Medicine, Kyoto University, ***Mitsubishi Kyoto Hospital, ****Takeda Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 26 |
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| Number | 6 |
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| Page | 723-731 |
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| Year/Month | 1989/6 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] A new scintigraphic method to detect myocardial necrosis has been developed using antimyosin monoclonal antibody F ab labeled with indium-111 (111In-antimyosin). We investigated 111In-antimyosin scintigraphy in 35 patients with myocardial infarction, 5 patients with myocarditis and 3 patients with angina pectoris. 111In-antimyosin F ab was administered iv and antimyosin images were recorded by planar and single photon emission computed tomography (SPECT) 48-72 hrs after injection. Planar images showed discrete localization of 111In-antimyosin in 26 of 27 patients within 16 days after the onset of acute myocardial infarction in 14 of whom creatine kinase, glutamic oxaloacetic transaminase and lactic dehydrogenase had already normalized. In addition, positive scans were also obtained in 4 of 8 patients 1 to 9 months after the onset of the disease. Three patients with acute myocarditis (two of whom were biopsy-proven) had positive scans 2 and 4 weeks after the onset of the disease. Although mechanism of persistent positive antimyosin images in the chronic stage remains to be clarified, 111In-antimyosin scintigraphy holds potential promise as a noninvasive method for the detection of myocardial injury. |
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| Practice | Clinical medicine |
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| Keywords | Antimyosin, Monoclonal antibody, Imaging, Myocarditis, Myocardial infarction. |
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