| Japanese |
|---|
| Title | N-Isopropyl-p-[123I]Iodoamphetamineの脳集積と全身動態との関連 |
|---|
| Subtitle | ≪原著≫ |
|---|
| Authors | 佐藤始広*, 武田徹**, 外山比南子**, 中島光太郎*, 石川演美**, 秋貞雅祥** |
|---|
| Authors(kana) | |
|---|
| Organization | *筑波大学附属病院放射線科, **臨床医学系放射線科 |
|---|
| Journal | 核医学 |
|---|
| Volume | 26 |
|---|
| Number | 5 |
|---|
| Page | 581-589 |
|---|
| Year/Month | 1989/5 |
|---|
| Article | 原著 |
|---|
| Publisher | 日本核医学会 |
|---|
| Abstract | 「要旨」N-isopropyl-p-[123I]iodoamphetamine (123I-IMP)の脳集積と他臓器の動態の関連性を特にearly画像とdelayed画像のカウント数の比に注目して検討した. 対象は脳血管障害患者10名, および脳血管障害の既往のない他の疾患患者11名, 計21名である. 大視野回転型ガンマカメラを用いて肺, 肝のdynamic scanを行うとともに, 脳のSPECT像を静注後早期と3時間後に撮影した. 肺, 肝, 脳の各臓器のカウント数から, delayed画像とearly画像の比の値(D/E ratio)を算出し, 各臓器の動態の関連性をearly画像の値およびD/E ratioを用いて検討した. その結果, 肺と健常側脳半球のD/E ratioの間には良好な正の相関が認められ, 肺と脳の集積変化には密接な関連が存在することが明らかとなった. また脳血管障害群において視覚的に正常のIMP分布を示す健常側半球のD/E ratioは, 他の疾患群のそれと比較すると全体に高い値を示し, かつバラつく傾向にあった. このことは脳血管障害患者においては正常と考えられる脳半球側においても血管病変を有することを示唆するものと考えられた. 一方, 肝と肺のD/E ratioの間には比較的良好な負の相関が認められた. また脳にdelayed画像で集積増加を示す症例ほど肝への集積は少ない傾向にあった. つまり肺から早く洗い出されるほど肝に早く集積を示し, また脳に多く再分布する症例ほど肝への集積は遅れるものと考えられた. 以上のように脳のIMP集積には他臓器の動態が密接に関連しており, delayed画像の評価に際してはその動態を考慮する必要があると考えられた. |
|---|
| Practice | 臨床医学：一般 |
|---|
| Keywords | N-isopropyl-p-[1231] iodoamphetamine (123I-IMP), Single photon emission CT (SPECT), Delayed image, Washout, Regional cerebral blood flow. |
|---|
| English |
|---|
| Title | The Relationship between N-Isopropyl-p-[123I]Iodoamphetamine Accumulation in the Brain and its Dynamics in Other Organs |
|---|
| Subtitle | - Original Articles - |
|---|
| Authors | Motohiro SATOH, Tohoru TAKEDA, Hinako TOYAMA, Kotaro NAKAJIMA, Nobuyoshi ISHIKAWA, Masayoshi AKISADA |
|---|
| Authors(kana) | |
|---|
| Organization | Department of Radiology, Institute of Clinical Medicine, University of Tsukuba |
|---|
| Journal | The Japanese Journal of nuclear medicine |
|---|
| Volume | 26 |
|---|
| Number | 5 |
|---|
| Page | 581-589 |
|---|
| Year/Month | 1989/5 |
|---|
| Article | Original article |
|---|
| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
|---|
| Abstract | [Summary] Single photon emission computed tomography of the brain and dynamic scintigraphy of the lung and liver with N-isopropyl-p-[123I]iodoamphetamine (IMP) were performed in 21 patients with and without cerebrovascular diseases to determine the relationship between IMP accumulation in the brain and its dynamics in other organs. The D/E ratios of the lung, liver and brain were calculated dividing the counts of the delayed image by that of the early image. The brain D/E ratio in the normal hemisphere was well correlated with the lung D/E ratio. So cases which showed more rapid lung washout tended to washout faster from the brain. We thought that this fact was affected by the systemic circulation. And the values of the brain D/E ratio of the cerebrovascular disease group were larger than that of the non-cerebrovascular disease group. This suggest the frequent existence of arteriosclerotic changes in patients of the cerebrovascular disease. Because the local brain washout was depended on the amount of the cerebral blood flow there. On the other hand, the lung D/E ratio was inversely correlated with the liver D/E ratio. In other words, more washout from the lung caused more accumulation of IMP in the liver. Also the brain D/E ratio was inversely correlated with the liver D/E ratio. In conclusion, there was a close relationship between IMP dynamics in the brain and that in other organs. |
|---|
| Practice | Clinical medicine |
|---|
| Keywords | N-isopropyl-p-[1231]iodoamphetamine (123I-IMP), Single photon emission CT (SPECT), Delayed image, Washout, Regional cerebral blood flow. |
|---|