| Japanese |
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| Title | N-Isopropyl-p-[123I]Iodoamphetamineの集積したGlioblastoma - 症例の経時的検討 |
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| Subtitle | 症例報告 |
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| Authors | 荒木有三*, 山田弘* |
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| Organization | *岐阜大学医学部脳神経外科 |
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| Journal | 核医学 |
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| Volume | 26 |
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| Number | 4 |
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| Page | 523-527 |
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| Year/Month | 1989/4 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 N-isopropyl-p-[123I]iodoamphetamine (IMP) の集積したglioblastomaの一例をSPECTにより経時的に観察し, その集積機序について検討した. 腫瘍部分はCTにて造影効果を有し, 脳血管写, 手術所見, 病理組織所見より腫瘍血管は豊富であった. Xe-SPECT, IMP-SPECT early image (IMP静注20分後) で腫瘍部分の血流量は健側皮質と比較して高値を示し, また, IMP-SPECT delayed image (IMP静注2時間後) においても皮質と同等の高集積が持続した. 電子線による術中照射, 超高圧X線外照射施行により, CTで造影される残存腫瘍部分の血流値 (Xe-SPECT) , およびIMPの集積は漸減したが, thallium-201を用いた腫瘍SPECTでは, 高集積域として示された. 以上よりIMPは腫瘍組織の血流量に応じて分布すると考えられたが, 動静脈吻合の存在する腫瘍組織ではIMPはトラップされないため, IMP-SPECT early imageは腫瘍組織の血流量と血管構築を反映した画像と考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | N-isopropyl-p-[123I]iodoamphetamine, SPECT, Glioblastoma, CBF, Thallium-201 |
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| English |
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| Title | Sequential Study of a Glioblastoma with High Uptake of N-Isopropyl-p-[123I]Iodoamphetamine : A Case Report |
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| Authors | Yuzo ARAKI, Hiromu YAMADA |
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| Authors(kana) | |
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| Organization | Department of Neurosurgery, Gifu University Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 26 |
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| Number | 4 |
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| Page | 523-527 |
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| Year/Month | 1989/4 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] A case of glioblastoma with high uptake of N-isopropyl-p-[123I]iodoamphetamine (IMP) is presented. The lesion on a X-ray CT showed an enhanced area with a cyst, in which angiography, operative findings and histological investigations revealed abundant vessels. A pretreatment Xe-SPECT study showed that the tumor blood flow was higher than a healthy cortex blood flow. Also, high IMP uptake was observed using an IMP-SPECT early image, 20 minutes after IMP intravenous injection. Furthermore it was noted in the delayed image 2 hours later. After intraoperative and external radiation therapy, both the tumor blood flow, as determined by Xe-SPECT, and the IMP uptake were seen to gradually decrease, while the thallium-201 uptake was high. These findings suggested that the IMP uptake in tumor tissue accurately reflects the tumor blood flow if there is no arteriovenous fistula in the tumor. On conclusion, IMP-SPECT early images might reflect both the tumor blood flow and the vascular architecture. |
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| Practice | Clinical medicine |
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| Keywords | N-isopropyl-p-[123I]iodoamphetamine, SPECT, Glioblastoma, CBF, Thallium-201 |
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