| Japanese |
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| Title | 123I-IMPの肺集積の検討 |
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| Subtitle | 原著 |
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| Authors | 謝花正信* |
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| Authors(kana) | |
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| Organization | *鳥取大学医学部放射線科 |
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| Journal | 核医学 |
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| Volume | 26 |
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| Number | 4 |
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| Page | 515-522 |
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| Year/Month | 1989/4 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 正常肺の20例と肺癌8例, 慢性閉塞性肺疾患19例, 肺線維症2例, 膠原病1例の計50例を対象として, 123I-IMPの肺集積について, MTTと喫煙および肺機能を検討した. 肺における123I-IMPの減衰曲線に関しては平均通過時間で評価したが, 肺癌を含めた肺疾患群における病変部では正常肺に比べて有意に延長していた. しかし良悪性の区別は困難であった. 一般肺機能, 血液ガスデータを変数に加えた因子分析では, 一般肺機能との相関は低く, 血液ガスデータと強い相関を示し, 肺胞レベルにおける代謝との因果関係が示唆された. 遅延像では慢性閉塞性肺疾患, 肺線維症で病変部に高集積を示した. しかし気腫性変化のみでは高集積を示さず, 133Xeによる洗い出し像とも解離していた. 肺癌例でも高率に高集積像を呈したが, その集積は腫瘍の周囲の肺実質と考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | N-isopropyl-p-[123I]-iodoamphetamine, Pulmonary accumulation of 123I-IMP, Lung cancer, COPD (chronic obstructive pulmonary disease) , Fibrosis |
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| English |
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| Title | Evaluation of Lung Scintigraphy Using N-Isopropyl-p-[123I]-Iodoamphetamine |
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| Subtitle | |
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| Authors | Masanobu SHABANA |
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| Authors(kana) | |
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| Organization | Department of Radiology, Tottori University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 26 |
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| Number | 4 |
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| Page | 515-522 |
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| Year/Month | 1989/4 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] N-isopropyl-p-[123I]-iodoamphetamine (123I- IMP) was examined for its relevancy as a labeling medium of lung scintigraphy in 30 patients with lung diseases and 20 healthy subjects. Lung diseases were classified into carcinoma and diffuse lung disease, and the all subjects with normal lung were classified into smokers and nonsmokers. To assess the reduction curve of 123I-IMP, mean transit time was calculated. Forced spirography was performed and spirographic values were analyzed. Spirographic parameters examined were vital capacity percent (%VC) , forced expiratory volume in 1 sec divided by forced vital capacity (%) (FEV1.0%) , and blood gas data. In the correlation matrix, the mean transit time was correlated with blood gas data, and not with %VC or FEV1.0%. In patients with lung diseases, the mean transit time was significantly prolonged ; however, the difference was not significant between groups of carcinoma and benign disease, and between groups of smokers and nonsmokers. Wash-out images were obtained by the subtraction technique using the first frame image and 100-min delayed image. In patients with lung carcinoma, 87.5% of the tumors were depicted on wash-out images. The lesions were also depicted well benign lung diseases. But among findings of wash-out image by 123I-IMP, air trapping image by 133Xe study and XCT study, there are some discordances to be clarified. |
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| Practice | Clinical medicine |
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| Keywords | N-isopropyl-p-[123I]-iodoamphetamine, Pulmonary accumulation of 123I-IMP, Lung cancer, COPD (chronic obstructive pulmonary disease) , Fibrosis |
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