Japanese
Titleクエン酸ガリウム (Ga-67) シンチグラフィによる転移性骨腫瘍の描出能
Subtitle原著
Authors小泉潔*, 内山暁*, 荒木力*, 日原敏彦*, 尾形均*, 門澤秀一*, 可知謙治*, 松迫正樹*
Authors(kana)
Organization*山梨医科大学放射線科
Journal核医学
Volume26
Number3
Page361-368
Year/Month1989/3
Article原著
Publisher日本核医学会
Abstract「要旨」 クエン酸ガリウム (Ga-67) を用いた腫瘍シンチグラフィにおいて, Tc-99m MDP骨シンチグラフィにて指摘されている転移性骨腫瘍の描出能に関して, 良性骨病変を対照として検討を加えた. 各種悪性腫瘍の骨転移巣47病巣中23病巣49%にガリウムの高度集積を認めた. それに対して, 加齢性変化あるいは外傷性疾患などの良性骨病変においては, 71病巣中ガリウムの高度集積を認めたのは7病巣10%のみであり, その大部分は骨折・骨切断後状態であった. 骨転移巣のガリウム集積性と原発巣のガリウム親和性とは必ずしも相関せず, したがって, 骨転移巣のガリウム集積機序は, 骨転移巣における腫瘍組織 (腫瘍細胞) への集積のみならず反応性の骨自体への集積も推察された.
Practice臨床医学：一般
KeywordsGa-67 scan, Bone metastasis, Bone scan, Benign bone lesion
English
TitleDetectability of Metastatic Bone Tumor by Ga-67 Scintigraphy
Subtitle
AuthorsKiyoshi KOIZUMI, Guio UCHIYAMA, Tsutomu ARAKI, Toshihiko HIHARA, Hitoshi OGATA, Shuichi MONZAWA, Kenji KACHI, Masaki MATSUSAKO
Authors(kana)
OrganizationDepartment of Radiology, Yamanashi Medical School
JournalThe Japanese Journal of nuclear medicine
Volume26
Number3
Page361-368
Year/Month1989/3
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary] Ga-67 scintigrams in patients with malignant diseases sometimes reveal uptake of the tracer in the bone metastases. Detectability of Ga-67 scintigraphy for metastatic bone tumors and benign bone lesions was compared with that of Tc-99m bone scintigraphy. Countable bone metastases detected by bone scintigraphy were evaluated whether the lesion showed apparent, faint, or negative Ga-67 uptake. Of 47 lesions 23 (49%) showed apparent uptake and 17 (36%) showed negative uptake. On the other hand, of 71 benign bone lesions, only 7 (10%) , mostly fracture/osteotomy, showed apparent uptake of the tracer. Uptake in the other benign lesions such as trauma of the ribs, spondylosis defbrmans, and arthrosis deformans was rather faint. In patients with multiple bone metastases, 9 patients (82%) out of 11 showed more prominent abnormal findings in Tc-99m MDP bone scintigraphy than in Ga-67 scintigraphy ; that is, Ga-67 scintigraphy was not able to reveal all metastatic bone lesions. In patients with untreated or recurrent tumors, relation between Ga-67 uptake in the tumors and that in the bone metastases was evaluated. Of 7 patients with negative Ga-67 uptake in the primary tumors, 5 showed positive Ga-67 uptake in the bone metastases ; that is, there seemed to be little relation between Ga-67 affinity to the primary tumors and that to the bone metastases. Mechanisms of the Ga-67 uptake in the bone metastases were discussed. Not only the tumor cells or tissues in the bone metastases but also bone mineral or osteoclasts might be the deposition sites of Ga-67.
PracticeClinical medicine
KeywordsGa-67 scan, Bone metastasis, Bone scan, Benign bone lesion

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