| Japanese |
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| Title | 単純ヘルペス脳炎患者におけるN-isopropyl-p-[123I]-iodoamphetamineおよび99mTc-hexamethyl propyleneamine oximeによるSingle Photon Emission Computed Tomography |
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| Subtitle | 症例報告 |
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| Authors | 小野志磨人*, 福永仁夫*, 大塚信昭*, 永井清久*, 森田浩一*, 村中明*, 古川高子*, 柳元真一*, 友光達志*, 河合謹豪**, 寺尾章**, 森田陸司* |
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| Authors(kana) | |
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| Organization | *川崎医科大学核医学科, **神経内科 |
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| Journal | 核医学 |
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| Volume | 26 |
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| Number | 2 |
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| Page | 239-251 |
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| Year/Month | 1989/2 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 70歳, 男性の単純ヘルペス脳炎(herpes simplex encephalitis, HSE)患者に, N-isopropyl-p-[123I]-iodoamphetamine(123I-IMP)および99mTc-hexamethyl propyleneamine oxime(99mTc-HM-PAO)によるsingle photon emission computed tomography(SPECT)を経時的に施行し, その集積の変化を検討した, HSEの病初期には, 123I-IMPおよび99mTc-HM-PAOの集積は増加し, 病期が進行するに従い, 集積は低下することが示された. また, 従来X線CTにて報告された病変の出現順序と同様に, HSEの病変は, まず側頭葉に始まり, ついで左後頭葉, 前頭葉に及ぶことが, 123I-IMPおよび99mTc-HM-PAO SPECTで示された. さらに, 両SPECTの所見は, HSEの臨床症状や髄液所見の消長をよく反映していた. このように, 123I-IMPおよび99mTc-HM-PAO SPECTは, HSEの診断, 治療方針の決定や病態解明に有用な手段であると思われた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-IMP, 99mTc-HM-PAO, SPECT, Herpes simplex encephalitis, Count ratio |
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| English |
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| Title | Single Photon Emission Computed Tomogmphy by Using N-isopropyl-p-[123I]-iodoamphetamine and 99mTC-hexamethyl Propyleneamine Oxime in a Patient with Herpes Simplex Encephalitis |
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| Subtitle | |
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| Authors | Shimato ONO*, Masao FUKUNAGA*, Nobuaki OTSUKA*, Kiyohisa NAGAI*, Koichi MORITA*, Akira MURANAKA*, Takako FURUKAWA*, Shinichi YANAGIMOTO*, Tatsushi TOMOMITSU*, Kingo KAWAI**, Akira TERAO**, Rikushi MORITA* |
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| Authors(kana) | |
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| Organization | *Department of Nuclear Medicine, **Department of Neurology, Kawasaki Medical School |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 26 |
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| Number | 2 |
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| Page | 239-251 |
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| Year/Month | 1989/2 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Single photon emission computed tomographies (SPECTs) by using N-isopropyl-p-[123I-IMP]-iodoamphetamine (123I-IMP) and 99mTc-hexamethyl propyleneamine oxime (99mTc-HM-PAO) were serially performed in a 70 yrs. old male with herpes simplex encephalitis (HSE), and the chronological changes of accumulations were studied. Accumulations of both 123I-IMP and 99mTc-HM-PAO increased initially, and then decreased with the stage of HSE being advanced. The sequential appearance of the lesion in HSE with 123I-IMP and 99mTc-HM-PAO SPECTs was as same as that reported previously by X-CT; beginning at the temporal lobe with eventually being spread to the occipital and frontal lobe. Furthermore, it was shown that findings of both SPECTs could reflect considerably the clinical features, and the laboratory data in central spinal fluid. Thus, 123I-IMP and 99mTc-HM-PAO SPECTs seemed to be a useful tool in the diagnosis, deciding of whether the treatment was suspended or continued, and clarifying the pathophysiology in HSE. |
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| Practice | Clinical medicine |
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| Keywords | 123I-IMP, 99mTc-HM-PAO, SPECT, Herpes simplex encephalitis, Count ratio |
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