| Japanese |
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| Title | 加齢に伴うヒト線条体D2ドーパミン受容体結合能の低下 - ポジトロン・エミッション・トモグラフィーによる測定 - |
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| Subtitle | 原著 |
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| Authors | 伊豫雅臣*,**, 山崎統四郎*, 福田寛*, 井上修*, 鈴木和年***, 篠遠仁*, 伊藤高司****, 米沢久司*, 西尾正人*, 古関安里*, 福井進**, 舘野之男* |
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| Authors(kana) | |
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| Organization | *放射線医学総合研究所臨床研究部, **国立精神・神経センター精神保健研究所 薬物依存研究部, ***放射線医学総合研究所サイクロトロン管理課, ****日本医科大学数学教室 |
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| Journal | 核医学 |
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| Volume | 26 |
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| Number | 2 |
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| Page | 213-220 |
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| Year/Month | 1989/2 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 11C-N-メチルスピペロン([11C]NMSP)をトレーサとして用いたポジトロン・エミッション・トモグラフィー(PET)検査を行い, 健常者11例(22歳から72歳)について加齢に伴う線条体[11C]NMSP結合の変化を調べた. 脳内での[11C]NMSP取り込みは線条体において最も高く, 大脳皮質で中等度, 小脳では低かった. 小脳の放射能動態を入力関数として算出した等価時間に対する線条体/小脳の放射能比の傾きから, [11C]NMSPと線条体D2受体容の結合速度定数k3を求めた. k3は加齢とともに指数関数的に減少し, 22歳男子で0.035/分であり, 72歳男子で0.020/分であった. この結果より, 加齢による線条体のD2受容体を介するドーパミン神経活動の減少が示唆された. |
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| Practice | 臨床医学：一般 |
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| Keywords | PET, 11C-N-methylspiperone, D2 dopamine receptor, Aging |
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| English |
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| Title | Age-related Decrease of 11C-N-methylspiperone In Vivo Binding to Human Striatum Detected by PET |
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| Authors | Masaomi IYo*,**, Toshiro YAMASAKI*, Hiroshi FUKUDA*, Osamu INOUE*, Kazutoshi SUZUKI***, Hitoshi SHINOTOH*, Takashi ITo****, Hisashi YONEZAWA*, Masato NISHIO*, Ari KOSEKI*, Susumu FUKUI**, Yukio TATENO* |
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| Authors(kana) | |
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| Organization | *Division of Clinical Research, National Institute of Radiological Sciences, **National Center of Neurology and Psychiatry, National Institute of Mental Health, ***Section of Cyclotron, National Institute of Radiological Scieces, ****Department of Mathematics, Nippon Medical School |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 26 |
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| Number | 2 |
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| Page | 213-220 |
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| Year/Month | 1989/2 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] The effect of aging on 11C-N-methylspiperone binding to living human striatum was demonstrated using positron emission tomography. The 11 normal volunteers (22 to 72 years old) participated in this study. The uptake of 11C-N-methylspiperone in the brain following intravenous injection was highest in the striatum in individual subject. And the uptake in the striatum only gradually increased until the end of the study. The uptake of 11C-N-methylspiperone in cerebellum peaked within 10 minutes following injection and then rapidly dropped. The association rate constant "k3" was calculated from the slope of the radioactivity-ratio of striatum to cerebellum versus the equivalent time. The equivalent time was calculated from the radioactivity of cerebellum as an input function. The exponential decrease of the k3 value with aging was observed. The k3 value of the youngest subject (22 years old, male) was 0.035/min, while that of the oldest one (72 years old, male) was found to be 0.020/min. These data suggested that the dopaminergic activity through D2 dopamine receptors reduces with aging in human striatum. |
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| Practice | Clinical medicine |
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| Keywords | PET, 11C-N-methylspiperone, D2 dopamine receptor, Aging |
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