| Japanese |
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| Title | 痴呆患者におけるrCBF測定中の終末呼気CO2濃度の変動とその影響および補正について |
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| Subtitle | 原著 |
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| Authors | 駒谷昭夫*, 山口昂一*, 螻眞弘*, 高梨俊保*, 篠原正夫**, 川勝忍**, 矢崎光保** |
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| Organization | *山形大学医学部放射線科, **精神科神経科 |
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| Journal | 核医学 |
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| Volume | 26 |
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| Number | 2 |
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| Page | 165-170 |
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| Year/Month | 1989/2 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 マウスピースによる呼吸は, 呼吸パターンの変化をきたしPaCO2を変動させる. その変動が脳血流に及ぼす影響と, 終末呼気CO2濃度による脳血流の補正について検討した. 痴呆患者の脳血流測定中の終末呼気CO2濃度は, 老年健常者(SC)に比し低く, かつ大きくばらつく傾向が認められた. この傾向はアルツハイマー病(AD), 中でもI期の中〜後期に著しく, 経過観察中この時期に異常な過小評価をする原因となることがわかった. AD群およびアルツハイマー型老年痴呆(SDAT)群の平均脳血流の終末呼気CO2濃度(%)に対する変化率は13.9±2.9%(3.6%/mmHg PaCO2に相当)で, 健常者の14.0±2.1%と有意の差はなかった. 脳血管障害を伴わない痴呆患者の脳血流補正はCO2反応性を一定とする終末呼気CO2濃度による補正が実用上可能であり, より正確な脳血流の評価にはマウスピース呼吸が及ぼす影響の補正は必須であると考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Cerebral blood flow, Demented patient, End-tidal CO2 concentration, Xe-133 inhalation method |
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| English |
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| Title | Effect of Breathing Fluctuations on Cerebral Blood Flow in Demented Patients and its Correction Method Usig End-Tidal CO2 Concentration |
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| Authors | Akio KOMATANI*, Koichi YAMAGUCHI*, Masahiro KERA*, Toshiyasu TAKANASHI*, Masao SHINOHARA**, Shinobu KAWAKATSU**, Mitsuyasu YAZAKI** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, **Department of Neuropsychiatry, Yamagata University School of Medcine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 26 |
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| Number | 2 |
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| Page | 165-170 |
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| Year/Month | 1989/2 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] During mouthpiece respiration of Xe-133 for a measurement of regional cerebral blood flow (rCBF), the breathing pattern of patients fluctuated and it caused a change of end-tidal CO2 concentration that had an excellent correlation with PaCO2 in patient without respiratory disease. The end-tidal CO2 concentration of demented patients varied within lower ranges than senile control group. The range of fluctuation on the end-tidal CO2 concentration was dependent on the type and the degree of dementia, and it fluctuated most widely at the middle stage of Alzheimer disease. Mean cerebral blood flow increased by 13.9% for each 1% increase in end-tidal CO2 concentration (3.6%/mmHg PaCO2) in the case of demented patients without cerebrovascular disease. To improve the reliability of rCBF in demented patients, especially in Alzheimer disease, the correction of rCBF data for end-tidal CO2 concentration should be performed. |
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| Practice | Clinical medicine |
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| Keywords | Cerebral blood flow, Demented patient, End-tidal CO2 concentration, Xe-133 inhalation method |
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