| Japanese |
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| Title | 因子分析を用いた肝胆道シンチグラフィによる肝機能の評価 |
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| Subtitle | 原著 |
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| Authors | 下村修*, 高橋睦正*, 辻明徳*, 高木善和*, 冨口静二*, 古閑幸則*, 古嶋昭博*, 松本政典*, 原正史*, 広田嘉久* |
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| Organization | *熊本大学医学部放射線科 |
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| Journal | 核医学 |
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| Volume | 26 |
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| Number | 2 |
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| Page | 145-153 |
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| Year/Month | 1989/2 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 99mTc-N-pyridoxyl-5-methyltryptophan(99mTc-PMT)による肝胆道シンチグラフィに因子分析を応用し, 肝実質の機能成分(ヘパトグラム)を求めた. 得られたヘパトグラムよりpeak timeとT1/2の2つのパラメータを求めたところ, ICG 15分停滞率といずれも良好な正の相関が得られ, 健常者→慢性肝炎→代償性肝硬変→非代償性肝硬変の順に遅延し, 肝機能の評価法として有用と思われた. 従来のROI法によるヘバトグラムでは, 肝内に大きな占拠性病変(SOL)や肝内胆嚢が存在したり, 肝内胆管の拡張がある場合, また肝硬変が著明で肝へのRI集積が不均一な場合などでは, ROIの大きさ, 設定位置により波型が変化し再現性に欠け, 肝全体としての機能の指標としては問題があるものと思われるが, 因子分析によるヘパトグラムの場合には, このような症例でもglobalな肝機能の評価ができ, 臨床的に有用な手段となり得ると思われた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Factor analysis, Hepatobiliary scintigraphy, 99mTc-PMT, Hepatogram |
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| English |
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| Title | Evaluation of Hepatic Function by Hepatobiliary Scintigraphy Using Factor Analysis |
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| Authors | Osamu SHIMOMURA, Mutsumasa TAKAHASHI, Akinori TSUJI, Yoshikazu TAKAGI, Seiji TOMIGUCHI, Yukinori KOGA, Akihiro KOJIMA, Masanori MATSUMOTO, Masafumi HARA, Yoshihisa HIROTA |
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| Authors(kana) | |
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| Organization | Department of Radiology, Kumamoto University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 26 |
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| Number | 2 |
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| Page | 145-153 |
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| Year/Month | 1989/2 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Factor analysis of hepatobiliary scintigraphy using 99mTc-N-pyridoxyl-5-methyltryptophan (99mTc-PMT) was performed, and functional factor of liver parenchyma (FA-hepatogram) was obtained. Two parameters (peak time, T 1/2） were calculated from this hepatogram. A good correlation was obtained between these parameters and ICG-R15; furthermore, these parameters were prolonged in patients with normal volunteers, chronic hepatitis, compensated and decompensated liver cirrhosis in this order. Conventional hepatogram by ROI method (ROI-hepatogram) was not suitable for the evaluation of global liver function in condition such as a large intrahepatic mass, intrahepatic gall bladder, dilatation of biliary tree, and severe liver cirrhosis. But, even in such cases, FA-hepatogram was useful for the evaluation of global liver function. |
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| Practice | Clinical medicine |
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| Keywords | Factor analysis, Hepatobiliary scintigraphy, 99mTc-PMT, Hepatogram |
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