| Japanese |
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| Title | N-isopropyl-[123I]-p-iodoamphetamineおよび99mTc-hexamethyl propyleneamine oxime SPECTにより経過を観察したCreutzfeldt-Jakob病の1例 |
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| Subtitle | 症例報告 |
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| Authors | 小野志磨人*, 福永仁夫*, 大塚信昭*, 永井清久*, 森田浩一*, 村中明*, 古川高子*, 柳元真一*, 友光達志*, 河合謹豪**, 寺尾章**, 森田陸司* |
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| Authors(kana) | |
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| Organization | *川崎医科大学核医学科, **神経内科 |
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| Journal | 核医学 |
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| Volume | 26 |
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| Number | 1 |
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| Page | 77-88 |
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| Year/Month | 1989/1 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 66歳, 女性のCreutzfeldt-Jakob病(CJD)に, N-isopropyl-[123I]-p-iodoamphetamine(123I-IMP)および99mTc-hexamethyl propyleneamine oxime(99mTc-HM-PAO)SPECTを経時的に行った. X線CTでは何ら異常がみられないCJDの病初期に, 123I-IMPおよび99mTc-HM-PAOの, 初めは限局しているが結局全脳に及ぶ集積の低下が観察された. 123I-IMPの集積が著明に低下する比較的早期には, 123I-IMPの再分布が認められたが, 病状の進行とともにみられなくなった. 病初期に急激な集積の低下を示した両薬剤は, 慢性期にはともに低下をしたままであった. 初回SPECTに対する集積の割合は, 第2同目以降のいずれの検査においても99mTc-HM-PAOの方が123I-IMPよりも低い値を示した. この原因として, 両薬剤の集積機序の違いが関与している可能性が示唆された. このように, CJDの経過を123I-IMPおよび99mTc-HM-PAO SPECTにより観察することは興味深く, CJDの病態解明に有用な情報を与えてくれるものと期待される. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-IMP, 99mTc-HM-PAO, SPECT, Creutzfeldt-Jakob disease |
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| English |
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| Title | A Case with Creutzfeldt-Jakob Disease Followed Up by N-Isopropyl-[123I]-p-Iodoamphetamine and 99mTC-Hexamethyl Propyleneamine Oxime SPECT |
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| Subtitle | |
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| Authors | Shimato ONO*, Masao FUKUNAGA*, Nobuaki OTSUKA*, Kiyohisa NAGAI*, Koichi MORITA*, Akira MURANAKA*, Takako FURUKAWA*, Shinichi YANAGIMOTO*, Tatsushi TOMOMITSU*, Kingo KAWAI**, Akira TERAO**, Rikushi MORITA* |
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| Authors(kana) | |
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| Organization | *Department of Nuclear Medicine, **Department of Neurology, Kawasaki Medical School |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 26 |
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| Number | 1 |
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| Page | 77-88 |
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| Year/Month | 1989/1 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] N-isopropyl-[123I]-p-iodoamphetamine (123I-IMP) and 99mTc-hexamethyl propyleneamine oxime (99mTc-HM-PAO) SPECT were performed in a 66 yrs-old female patient with Creutzfeldt-Jakob disease (CJD). The decreased accumulation of both radiopharmaceuticals, which localized initially in the focal regions and progressed eventually to the whole brain, were observed in the early stage of CJD, when no abnormal findings were obtained on X-CT. Although the redistribution of 123I-IMP was recognized in the relatively early stage in which the accumulation was significantly decreased, it disappeared with the progression of the disease. The accumulation of both radiopharmaceuticals which decreased remarkably in the early stage of CJD was sustained in low level during the chronic stage. The accumulation ratio of 99mTc-HM-PAO, after second examinations, to that on first SPECT was lower than those of 123I-IMP. It was suggested, as this cause, that the difference of the accumulation mechanism of both agents might be concerned. Thus, it is interested to follow up a patient with CJD by using 123I-IMP and 99mTc-HM-PAO SPECT, and this modality will provide a useful information to clarify the pathogenesis of CJD. |
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| Practice | Clinical medicine |
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| Keywords | 123I-IMP, 99mTc-HM-PAO, SPECT, Creutzfeldt-Jakob disease |
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