Japanese
Title肺癌および炎症性肺疾患における123I-IMP肺シンチグラフィdelayed像の検討
Subtitle原著
Authors末松徹*, 楢林勇*, 高田佳木*, 大林加代子*, 平田勇三*, 押谷高志*, 加納恭子*, 坂本武茂*, 込山豊蔵*, 吉野朗*, 坪田紀明**, 八田健**, 加堂哲治***, 山本裕之***
Authors(kana)
Organization*兵庫県立成人病センター放射線科, **胸部外科, ***呼吸器科
Journal核医学
Volume26
Number1
Page45-53
Year/Month1989/1
Article原著
Publisher日本核医学会
Abstract「要旨」 肺癌27例および炎症性肺疾患10例を対象に123I-IMP肺シンチグラフィを施行し, delayed像の有用性について検討した. 検査はRI注射24時間後に行い, 10症例ではSPECT収集を行った. 肺癌における123I-IMP集積パターンを5型に分類したが, 組織型による特徴ある所見は認めなかった. 集積パターンの変化は腫瘤の大きさと局在部位に関与するものであった. 肺癌では腫瘍部は欠損し, 腫瘤の辺縁部, あるいは末梢の無気肺および閉塞性肺炎に集積増加がみられた. 炎症性肺疾患では活動性を有する症例においては肺胞性, 間質性を問わず集積増加を認めた. 123I-IMPは無気肺および炎症に集積し, その機序としては, 肺内アミン代謝に加え, 肺表面活性の変化, microatelectasisの形成, 肺毛細管の透過性の亢進などが複合的に関与していることが示唆された. 本検査は腫瘍と, 無気肺および炎症との鑑別に有用であると考えた.
Practice臨床医学：一般
Keywords123I-IMP, Lung, Lung cancer, Pneumonia, Atelectasis
English
TitleDelayed Lung Scintigraphy with N-Isopropyl-I-123-p-Iodoamphetamine in Lung Cancer and Inflammatory Disease
Subtitle
AuthorsToru SUEMATSU*, Isamu NARABAYASHI*, Yoshiki TAKADA*, Kayoko OHBAYASHI*, Yuzo HIRATA*, Takashi OSHITANI*, Kyoko KANOH*, Takeshige SAKAMOTO*, Toyozo KOMIYAMA*, Akira YOSHINO*, Noriaki TSUBOTA**, Takeshi HATTA**, Tetsuji KADOH***, Hiroshi YAMAMOTO***
Authors(kana)
Organization*Department of Radiology, Hyogo Medical Center for Adults, **Department of Thoracic Surgery, Hyogo Medical Center for Adults, ***Department of Respiratory Disease, Hyogo Medical Center for Adults
JournalThe Japanese Journal of nuclear medicine
Volume26
Number1
Page45-53
Year/Month1989/1
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary] Lung studies with N-Isopropyl-I-123-p-Iodoamphetamine (IMP) were performed on patients with lung cancer or inflammatory disease. In the present study, we evaluated the usefulness of the delayed scintigraphy. The subjects consisted of 27 patients with lung cancer (34 lesions), 3 with radiation pneumonitis, 2 with interstitial pneumonitis, 2 with old tuberculous lesion (tuberculomas), 1 with diffuse panbronchiolitis, 1 with pneumonia and 1 with lung abscess. The delayed scintigraphy was performed 24 hr after intravenous injection of 3 mCi IMP, in sitting position. In 10 patients, SPECT images were obtained following the delayed scintigraphy. Delayed scintigraphic appearances of lung cancer were classified into 5 types, high IMP uptake in the area congruent with the lesion of atelectasis and/or obstructive pneumonia (Type I), high IMP uptake in the area surrounded the tumor (Type II), a defect in the area consistent with the tumor and no high IMP uptake in the area surrounded the tumor (Type III), high IMP uptake in the area almost congruent with the tumor (Type IV) and no significant change (Type V). Excluding 10 lesions with Type IV or V, no IMP uptake was seen in the areas congruent with the tumors. Type II was the most frequently observed pattern. Normal scintigrams (Type V) were observed in 8 lesions, whose sizes were fairly small. There was no definite trend caused by difference in histological types of cancers. In 8 patients with viable inflammatory disease of the lung, the delayed scintigrams showed high IMP uptake in the areas congruent with the abnormalities on chest roentgenograms. On the other hand, no uptake was seen in the old tuberculous lesions. The present study demonstrated that IMP did not accumulate in the tumors, and that high concentration of IMP was related to atelectasis and/or inflammation. We conclude that the delayed lung scintigraphy with IMP is diagnostically useful in detecting atelectasis and inflammation, and in distinguishing these lesions from lung cancer.
PracticeClinical medicine
Keywords123I-IMP, Lung, Lung cancer, Pneumonia, Atelectasis

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