| Japanese |
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| Title | 脳疾患患者に対する局所脳循環動態の検討 - 99mTc-HSA-Dと99mTc-HSAの比較を中心に - |
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| Subtitle | 原著 |
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| Authors | 石井勝己*, 中沢圭治*, 田所克巳*, 池田俊昭*, 高松俊道*, 渡辺潤一*, 依田一重*, 松林隆*, 坂井文彦**, 鈴木秀一** |
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| Authors(kana) | |
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| Organization | *北里大学医学部放射線科, **内科 |
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| Journal | 核医学 |
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| Volume | 26 |
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| Number | 1 |
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| Page | 35-44 |
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| Year/Month | 1989/1 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 従来, われわれは脳RIアンギオ, 局所脳血液量, 脳血液ヘマトクリット値と末梢血ヘマトクリット値の比(α)の測定に99mTc-RBCと99mTc-HSAを用いてきたが, 99mTc-HSAは血中での標識安定性に問題があった. 今回血中での標識安定性が良いと言われている既調製製剤である99mTc-HSA-Dの基礎的検討と臨床応用を試み, 99mTc-RBCおよび99mTc-HSAと比較検討した. 99mTc-HSA-D, 99mTc-RBCは, 静注60分後でも90%以上の血中保持率が保たれ, 良好なSPECT像が得られているのに比して99mTc-HSAは60%台と不安定であり, 臨床的にも99mTc-HSAは遊離した99mTcO4-による異常集積がSPECT像に出現するなど問題点が認められた. 99mTc-HSA-Dに由来する副作用, 臨床検査値異常も認められず, これらの測定には99mTc-HSA-Dを用いることが望まれる結果となった. |
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| Practice | 臨床医学：一般 |
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| Keywords | Local cerebral blood volume, SPECT, 99mTc-DTPA-HSA, 99mTc-HSA |
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| English |
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| Title | Local Cerebral Circulation Dynamic Study in Patients with Cerebral Diseases - Using 99mTc-HSA-D Mainly Compared with 99mTc-HSA - |
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| Subtitle | |
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| Authors | Katsumi ISHII*, Keiji NAKAZAWA*, Katsumi TADOKORO*, Toshiaki IKEDA*, Toshimichi TAKAMATSU*, Jun-ichi WATANABE*, Kazushige YODA*, Takashi MATSUBAYASHI*, Fumihiko SAKAI**, Shuichi SUZUKI** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, School of Medicine, Kitasato University, **Department of Internal Medicine, School of Medicine, Kitasato University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 26 |
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| Number | 1 |
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| Page | 35-44 |
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| Year/Month | 1989/1 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] We have been using 99mTc-RBC and 99mTc-HSA for cerebral angiography and measurement of the local cerebral blood volume (LCBV) and cerebral/peripheral hematocrit ratio (α). 99mTc-HSA, however, has a problem of poor stability in the blood. We conducted basic and clinical studies on 99mTc-HSA-D, a ready-to-use preparation with good stability in the blood. We measured the regional cerebral circulation dynamics in patients with cerebral diseases in comparison with 99mTc-RBC and 99mTc-HSA. 99mTc-HSA-D and 99mTc-RBC showed more than a 90% retention ratio in the blood 60 min after administration, and good SPECT images were obtained using these two pharmaceuticals. On the contrary, 99mTc-HSA was unstable and its retention ratio was 60s% 60 min after administration. 99mTc-HSA does not provide good SPECT images due to free 99mTcO4- which seems to be liberated from 99mTc-HSA in the body, etc. There were no adverse reactions or abnormal laboratory findings caused by the 99mTc-HSA-D administration in any of the patients. Based on these results, it is surmised that 99mTc-HSA-D is clinically useful for measurement of the cerebral blood volume and cerebral/peripheral hematocrit ratio (α). |
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| Practice | Clinical medicine |
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| Keywords | Local cerebral blood volume, SPECT, 99mTc-DTPA-HSA, 99mTc-HSA |
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