| Japanese |
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| Title | 18F-フロロフェニルアラニンによる脳腫瘍の診断 |
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| Subtitle | 研究速報 |
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| Authors | 宍戸文男*, 村上松太郎*, 三浦修一*, 高橋和弘*, 犬上篤*, 戸村則昭*, 日向野修一*, 藤田英明*, 菅野巖*, 佐々木広*, 飯田秀博*, 峯浦一喜**, 上村和夫* |
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| Authors(kana) | |
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| Organization | *秋田県立脳血管研究センター放射線科, **秋田大学医学部脳神経外科 |
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| Journal | 核医学 |
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| Volume | 25 |
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| Number | 12 |
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| Page | 1431-1435 |
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| Year/Month | 1988/12 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 18F-フロロフェニルアラニン(18F-Phe)を合成し, 腫瘍組織での挙動と脳腫瘍診断の有用性について, ポジトロンCT(PET)による動態計測を行い, 11C-メチオニン(11C-Met)と比較検討した. 3コンパートメントモデルを仮定し, dynamic scan, 経時的動脈血漿の放射活性から, 速度定数である, k1, k2, k3を求めた. 脳腫瘍組織では18-Pheでのk値は11C-Metと比較してk1, k2は同程度であったが, k3は著しい低値でほぼ0に近い値を示した. 一方, 一定時間後の大脳皮質に対する脳腫瘍組織の比をみると18F-Pheが1.68, 11C-Metが1.75と両者とも高く, 画像上でも脳腫瘍が陽性に描画された. これらのことから18F-Pheはアミノ酸のトランスポートを評価するトレーサであり, 11C-Metとは挙動を異にするが, 脳腫瘍の位置の検出やその範囲の同定などの診断には11C-Metと同様, 非常に有用と考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 18F-fluorophenylalanine, 11C-methionine, Brain tumor, Positron emission tomography |
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| English |
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| Title | Clinical Investigation of 18F-Fluorophenylalanine for Brain Tumor Imagmg - Comparison with 11C-Methionine - |
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| Authors | Fumio SHISHIDO*, Matsutaro MURAKAMI*, Shuichi MIURA*, Kazuhiro TAKAHASHI*, Atsushi INUGAMI*, Noriaki TOMURA*, Shuichi HIGANO*, Hideaki FUJITA*, Iwao KANNO*, Hiroshi SASAKI*, Hidehiro IIDA*, Katsuyoshi MINEURA**, Kazuo UEMURA* |
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| Authors(kana) | |
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| Organization | *Department of Radiology and Nuclear Medicine, Research Institute for Brain and Blood Vessels-Akita, **Department of Surgical Neurology, Akita University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 25 |
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| Number | 12 |
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| Page | 1431-1435 |
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| Year/Month | 1988/12 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Amino acids labeled with positron emitters offer the distinct advantages for diagnosis of brain tumors. We developed a radiopharmaceutical for brain tumors, which was 18F-fluorophenylalanine (18F-Phe). To determine the potential usefulness for brain tumors, we carried out clinical studies with this compound, and compared it with 11C-L-methionine (11C-Met). One normal volunteer and 3 patients with brain tumor were studied with the two tracers. The agents were rapidly injected intravenously. Time activity curves of the tracers in the brain and tumor tissue, and arterial blood were measured quantitatively by dynamic PET scan and arterial blood sampling, respectively. Assuming the three-compartment model to apply, the rate constants and metabolic rates of 18F-Phe and 11C-Met were calculated, and the parameters were compared with each other. In normal brain tissues of gray matter, mean value of metabolic rate of phenylalanine was 0.064 nmol/ml/min, and that of methionine was 0.41 nmol/ml/min, assuming that the lumped constant equals 1.0. In tumor tissue, mean value of metabolic rate of phenylalanine was 0.019 nmol/ml/min, and that of methionine was 0.62 nmol/ml/min. From these preliminary data, 18F-Phe is likely to evaluate a transport of amino acids and to be of diagnostic value for patients with brain tumors. |
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| Practice | Clinical medicine |
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| Keywords | 18F-fluorophenylalanine, 11C-methionine, Brain tumor, Positron emission tomography |
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