| Japanese |
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| Title | I-123 Metaiodobenzylguanidine (MIBG) による percutaneous transluminal coronary thrombolysis (PTCR) 例における心筋交感神経機能の評価 |
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| Subtitle | 研究速報 |
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| Authors | 田中健*, 相澤忠範*, 加藤和三*, 中野元*, 五十嵐正樹*, 上野孝志*, 広沢弘七郎**, 日下部きよ子*** |
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| Authors(kana) | |
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| Organization | *心臓血管研究所, **東京女子医科大学心臓血圧研究所, ***放射線科 |
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| Journal | 核医学 |
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| Volume | 25 |
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| Number | 12 |
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| Page | 1425-1429 |
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| Year/Month | 1988/12 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「I. はじめに」 Metaiodobenzylguanidine(MIBG)は心筋の交感神経末梢に取り込まれる. しかし, I-123 MIBGの心筋摂取率は低く, 画像化が困難なためか, 臨床報告はきわめて少ない. 著者らは, I-123 MIBG((株)第一ラジオアイソトープ研究所製)とTl-201の二核種同時収集法(dual mode)により, I-123 MIBG心筋像(MIBG像)を容易に得た. 今回, 本法をPTCR例に適用し, Tl-201心筋像(Tl像)正常部位に生じたMIBG像欠損範囲は, PTCRにより救われた急性期虚血領域の一部に対応し, この部位の交感神経機能が亜急性期でも異常なことが示されたので報告する. 「II. 方法」 対象は, 1988年4, 5月に急性心筋梗塞で心臓血管研究所に入院し, PTCRを受けた6例である. 検査は発症後平均16日目, 血行動態が落ち着いた時になされた. |
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| Practice | 臨床医学：一般 |
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| Keywords | I-123 (metaiodobenzylguanidine) MIBG, Myocardial sympathetic neuronal images, Dual mode, Thrombolysis, Denervation |
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| English |
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| Title | Estimation of Myocardial Sympathetic Neuronal Function with I-123 Metaiodobenzylguanidine (MIBG) in Patients with Acute Myocardial Infarction Undergoing Percutaneous Transluminal Coronary Thrombolysis (PTCR) |
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| Subtitle | |
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| Authors | Takeshi TANAKA*, Tadanori AIZAWA*, Kazuzo KATO*, Hajime NAKANO*, Masaki IGARASHI*, Takashi UENO*, Kiyoko KUSAKABE**, Koshichiro HIROSAWA** |
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| Authors(kana) | |
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| Organization | *The Cardiovascular Institute, **Tokyo Womens Medical College |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 25 |
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| Number | 12 |
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| Page | 1425-1429 |
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| Year/Month | 1988/12 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] I-123 MIBG is taken up by sympathetic nerve endings and provides myocardial sympathetic neuronal images. I-123 MIBG and Tl-201 dual collection mode was applied for 6 patients with acute myocardial infarctions. They underwent PTCR and 5 of 6 received PTCA. In late stage stress Tl-201 myocardial test was performed. MIBG images were obtained on average 16 days after PTCR. Marked discrepancy was noted between two kinds of images and generally MIBG lesions were larger. In MIBG images all 6 patients showed definite defects, however in Tl images 3 of 6 patients showed no defect, 2 with slight hypoperfusion area and 1 with small defect. No relationship was noted between defect size and degree of elevation of enzyme. In stress images 3 patients showed ischemic region and size of lesion was similar to those noted in I-123 MIBG images. This suggested that lesions noted in MIBG images resulted from severe ischemia during attack and in this region sympathetic function was depressed long after myocardial perfusion had been restored. The lesions noted in MIBG images might be salvaged by PTCR. MIBG images may be useful for estimating effect of PTCR. |
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| Practice | Clinical medicine |
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| Keywords | I-123 (metaiodobenzylguanidine) MIBG, Myocardial sympathetic neuronal images, Dual mode, Thrombolysis, Denervation |
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