| Japanese |
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| Title | 123I-脂肪酸 (β-methyl iodophenyl pentadecanoic acid : BMIPP) による心筋イメージング : 心筋梗塞 (閉塞群, 再開通群) における心筋血流, 代謝に関する研究 |
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| Subtitle | 原著 |
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| Authors | 西村恒彦*, 佐合正義*, 木原浩一*, 岡尚嗣*, 下永田剛*, 片渕哲朗*, 与小田一郎*, 林真*, 植原敏勇*, 林田孝平*, 野田裕幸**, 高野久輝** |
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| Authors(kana) | |
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| Organization | *国立循環器病センター放射線診療部, **人工臓器部 |
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| Journal | 核医学 |
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| Volume | 25 |
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| Number | 12 |
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| Page | 1403-1415 |
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| Year/Month | 1988/12 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 心筋エネルギー代謝の重要な役割を脂肪酸のβ酸化が担っている. したがって, 心筋脂肪酸イメージングは心筋のviabilityを評価する上で大切である. 123I標識側鎖脂肪酸である123I-BMIPPを用い, 雑種成犬にて心筋イメージング製剤としての有用性と心筋梗塞(閉塞群8例, 再開通群6例)において心筋血流と代謝イメージングを比較検討した. 123I-BMIPP血中消失は速やかで(T 1/2=0.8min), 心筋集積は高く, 心筋からの排泄は緩徐であった. 再開通部位では正常部位に比し心筋からの排泄(T 1/2)は, 有意に延長していた. 摘出心のイメージでは, 再開通部位は201TlClで陰性像として描出されたが, 123I-BMIPPでは陽性像ないし欠損程度は小さく描出された. 一方, 心筋梗塞(閉塞)群では, 201TlCl, 123I-BMIPPともに欠損像として描出された. 両イメージにおける差異はcircumferential profile analysisおよび組織カウンティング法で定量的に評価できた. このように, 本研究から心筋血流と代謝の解離が存在する状態があることが示された. 今後, 123I-BMIPPは虚血性心疾患を中心として, 心筋イメージング製剤としての有用性と併せ, 心筋viabilityの評価に用いられる可能性が示唆された. |
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| Practice | 臨床医学：一般 |
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| Keywords | Fatty acid metabolism, Thallium, 123I-BMIPP, Myocardial infarction |
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| English |
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| Title | Fatty Acid Myocardial Imaging Using 123I-β-methyl Iodophenyl Pentadecanoic Acid (BMIPP) : Comparison of Myocardial Blood Perfusion and Fatty Acid Metabolism in Canine Myocardial Infarction (Occlusion and Reperfusion Model) |
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| Authors | Tsunehiko NISHIMURA*, Masayoshi SAGO*, Koichi KIHARA*, Hisashi OKA*, Tsuyoshi SHIMONAGATA*, Tetsuro KATABUCHI*, Ichiro YOKOTA＊, Makoto HAYASHI*, Toshiisa UEHARA*, Kohei HAYASHIDA*, Hiroyuki NODA**, Hisateru TAKANO** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, **Department of Artificial Organ, National Cardiovascular Center |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 25 |
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| Number | 12 |
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| Page | 1403-1415 |
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| Year/Month | 1988/12 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] To evaluate myocardial perfusion and fatty acid metabolism in canine myocardial infarction (occlusion and reperfusion model), 16 dogs were studied using thallium and 123I-β-methyl iodophenyl pentadecanoic acid (BMIPP). There were 2 dogs with normal control, 8 dogs with left anterior coronary arterial occlusion (6 hr ligation) and 6 dogs with reperfusion (3 hr ligation and 1 hr reperfusion). BMIPP was considered as an excellent myocardial imaging agent, because of its higher uptake and longer retention in myocardium. Reperfused myocardium demonstrated marked prolongation of mean half-time value which was generated from BMIPP myocardial clearance curve. The gamma-camera imaging of the excised heart showed the uncoupling of BMIPP and thallium (BMIPP uptake greater than thallium) in 5 of 6 dogs. On the other hand, BMIPP and thallium had persistent defect at occluded myocardium. These uncoupling at reperfused myocardium may be caused by the increase of triglyceride content. Our data suggests that the combination of BMIPP and thallium may supply different information about zone of infarction and ischemia and should be performed in clinical study for the assessment of myocardial viability. |
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| Practice | Clinical medicine |
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| Keywords | Fatty acid metabolism, Thallium, 123I-BMIPP, Myocardial infarction |
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