| Japanese |
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| Title | 脳腫瘍における99mTc-hexamethylpropyleneamine oximeによるSingle Photon Emission Computed Tomography (SPECT) : N-isopropyl-[123I]-p-iodoamphetamineおよび99mTc-DTPA SPECTとの比較 |
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| Subtitle | 原著 |
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| Authors | 小野志磨人*, 福永仁夫*, 大塚信昭*, 永井清久*, 森田浩一*, 村中明*, 古川高子*, 柳元真一*, 友光達志*, 渡辺明良**, 石井鐐二**, 森田陸司* |
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| Authors(kana) | |
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| Organization | *川崎医科大学核医学科, **脳外科 |
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| Journal | 核医学 |
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| Volume | 25 |
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| Number | 12 |
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| Page | 1371-1379 |
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| Year/Month | 1988/12 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 脳腫瘍における血流を評価するために, 原発性脳腫瘍10例(星細胞腫2例, 膠芽腫3例, 髄膜腫4例および神経鞘腫1例)について, 99mTc-HM-PAO SPECTを施行し, その集積状態を観察するとともに, 123I-IMPおよび99mTc-DTPA SPECTの所見と比較, 検討した. 腫瘍部への99mTc-HM-PAOの集積は, 5例(星細胞腫1例, 膠芽腫1例および髄膜腫3例)で観察された. 一方, 123I-IMPの集積は3例で認められたが, その集積の程度は99mTc-HM-PAOに比して低く, しかも両薬剤で集積パターンが異なる症例もみられた. 腫瘍部への99mTc-HM-PAOの集積は, 99mTc-DTPAとは異なり, 後期像でも比較的良好に保たれていた. このように, 脳腫瘍に99mTc-HM-PAO SPECTを行うことは, 腫瘍部の血流状態の解明に有用な手段であると考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Brain tumor, SPECT, 99mTc-hexamethylpropyleneamine oxime, N-isopropyl-[123I]-p-iodoamphetamine, 99mTc-DTPA |
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| English |
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| Title | Single Photon Emission Computed Tomography (SPECT) Using 99mTc-hexamethylpropyleneamine Oxime in Brain Tumor : Comparison of N-isopropyl-[123I]-p-iodoamphetamine and 99mTC-DTPA SPECT |
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| Subtitle | |
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| Authors | Shimato ONO*, Masao FUKUNAGA*, Nobuaki OTSUKA*, Kiyohisa NAGAI*, Koichi MORITA*, Akira MURANAKA*, Takako FURUKAWA*, Shinichi YANAGIMOTO*, Tatsushi TOMOMITSU*, Akira WATANABE**, Ryoji ISHII**, Rikushi MORITA* |
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| Authors(kana) | |
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| Organization | *Department of Nuclear Medicine, **Department of Neurosurgery, Kawasaki Medical School |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 25 |
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| Number | 12 |
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| Page | 1371-1379 |
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| Year/Month | 1988/12 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] To evaluate the blood flow in the brain tumor, 99mTc-HM-PAO SPECT was performed in 10 patients with primary brain tumors (2 astrocytoma, 3 glioblastoma, 4 meningioma and 1 neurinoma). The accumulation of 99mTc-HM-PAO in the tumor was observed and semi-quantitatively estimated, and these findings were compared with those of 123I-IMP and 99mTc-DTPA. On 99mTc-HM-PAO, moderate to high accumulation was seen in 5 patients (1 astrocytoma, 1 glioblastoma and 3 meningioma), while on 123I-IMP SPECT in 3 patients. The accumulation of 123I-IMP in the tumor was lower in its degree when compared with 99mTc-HM-PAO. Furthermore, in some patients the different uptake patterns were observed between two radiopharmaceuticals. Unlikely to 99mTc-DTPA, 99mTc-HM-PAO was relatively fully retained in the tumor, even in the delayed phase. Thus, it was shown that 99mTc-HM-PAO SPECT in the brain tumor was a useful tool in clarifying its regional blood flow. |
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| Practice | Clinical medicine |
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| Keywords | Brain tumor, SPECT, 99mTc-hexamethylpropyleneamine oxime, N-isopropyl-[123I]-p-iodoamphetamine, 99mTc-DTPA |
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