| Japanese |
|---|
| Title | SPECTによるTc-99m(Sn)-N-pyridoxyl-5-methyltryptophan (Tc-99m-PMT) の全肝および単位体積当たりの肝摂取率測定 |
|---|
| Subtitle | 原著 |
|---|
| Authors | 中村和義*, 前田寿登*, 中川毅*, 佐久間肇*, 北野外紀雄**, 竹田寛*, 山口信夫* |
|---|
| Authors(kana) | |
|---|
| Organization | *三重大学医学部放射線医学教室, **附属病院中央検査部 |
|---|
| Journal | 核医学 |
|---|
| Volume | 25 |
|---|
| Number | 12 |
|---|
| Page | 1363-1369 |
|---|
| Year/Month | 1988/12 |
|---|
| Article | 原著 |
|---|
| Publisher | 日本核医学会 |
|---|
| Abstract | 「要旨」 SPECTによりTc-99m-PMT投与4-5分後の全肝および単位体積当たりの摂取率を測定した. 吸収補正はChangの一次補正法により行い, 吸収係数は肝ファントム実験にて求めたμ=0.115cm-1の値を用いた. 吸収補正された肝ファントム像の均一性に関しては, 最大カウントの70%以上領域にて各ボクセル値の変動係数は0.094であった. 単位体積当たりの肝摂取率は循環血液量に逆比例するため, 循環血液量を乗じて補正し, それをUi(t)indexとした. 求めた全肝摂取量は同時に測定したTc-99m-PMTの血中停滞率と良好な負の相関(r=-0.847, p<0.001, n=33)を, ICG血漿消失率と良好な正の相関(r=0.877, P<0.001, n=15)を示し, 信頼できるものと考えられた. また, 全肝摂取率と平均Ui(t)indexには良好なる相関(r=0.851, P<0.001, n=36)がみられたが, 全肝摂取率が同じでもUi(t)indexに約2倍近くの差を示す症例がみられた. 全肝および単位体積当たりの摂取率同時測定により, より正確な肝機能評価が可能であった. |
|---|
| Practice | 臨床医学：一般 |
|---|
| Keywords | Tc-99m-PMT, Hepatic uptake, SPECT, Regional liver function, Hepatobiliary imaging |
|---|
| English |
|---|
| Title | Estimation of Total Liver Uptake and Liver Uptake per Unit of Liver Volume of Tc-99m(Sn)-N-pyridoxyl-5-methyltryptophan (Tc-99m-PMT) Using SPECT |
|---|
| Subtitle | |
|---|
| Authors | Kazuyoshi NAKAMURA, Hisato MAEDA, Tsuyoshi NAKAGAWA, Hajime SAKUMA, Tokio KITANO, Kan TAKEDA, Nobuo YAMAGUCHI |
|---|
| Authors(kana) | |
|---|
| Organization | Department of Radiology, School of Medicine, Mie University |
|---|
| Journal | The Japanese Journal of nuclear medicine |
|---|
| Volume | 25 |
|---|
| Number | 12 |
|---|
| Page | 1363-1369 |
|---|
| Year/Month | 1988/12 |
|---|
| Article | Original article |
|---|
| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
|---|
| Abstract | [Summary] Total and regional liver function was evaluated by measuring total liver uptake(TLU) and liver uptake per unit of liver volume(LU/LV) of Tc-99m-PMT using SPECT. SPECT data were collected for 1 min starting at 4 min after bolus injection of Tc-99m-PMT. Attenuation and scatter correction for γ-rays was performed with a first order correction of Changs method using an attenuation coefficient of O.115 cm-1, which was determined in our liver phantom experiment. The coefficient of variation over the corrected liver phantom images with a cut off level of 70% was 0.094. LU/LV is inversely proportional to the circulating blood volume so that LU/LV was multiplied by blood volume to be determined as Ui(4-5)index. Thirty six patients were examined. Normal value in 9 volunteers was 61.0+-4.6% (mean+-S.D.) and 196+-19.8ml・%/cm3 for TLU and mean Ui(4-5)index, respectively. TLU was well negatively correlated with blood retention rate (r=-0.847;p<0.001;n=33) and also well correlated with plasma disappearance rate of ICG (r=0.877;p<0.001;n=15), TLU had a good correlation with mean Ui(4-5)index (r=0.851;p<0.001;n=36), though there were some cases who had as much as twice differences is mean Ui(4-5)index against the same levels of the TLU. This method was considered to be valuable for clinical study because it provides both total liver function and regional function per unit of liver volume, including the information on appropriate liver volume and because it is a very simple and not time-consuming test, being to be performed along with a routine Tc-99m-PMT imaging. |
|---|
| Practice | Clinical medicine |
|---|
| Keywords | Tc-99m-PMT, Hepatic uptake, SPECT, Regional liver function, Hepatobiliary imaging |
|---|