| Japanese |
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| Title | 痴呆におけるN-Isopropyl I-123 p-Iodoamphetamine (I-123IMP) SPECT |
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| Subtitle | 原著 |
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| Authors | 百瀬敏光*, 小坂昇*, 西川潤一*, 吉川宏起*, 大嶽達*, 渡辺俊明*, 岩田誠**, 清水輝夫**, 飯尾正宏* |
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| Organization | *東京大学医学部放射線科, **脳研神経内科 |
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| Journal | 核医学 |
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| Volume | 25 |
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| Number | 12 |
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| Page | 1311-1317 |
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| Year/Month | 1988/12 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 痴呆を呈する疾患10例〔アルツハイマー病(AD)6例, ピック病(PD)2例, クロイツフェルトヤコブ病(CJD)2例〕と正常者5例の計15例に対し, N-Isopropyl I-123 p-Iodoamphetamine(IMP)を用いたSPECTを施行し, 各症例の脳内IMP集積の対小脳比を算出し, 各疾患例と正常群を比較し病変部を検出するとともに, MRI, X線CTの所見と対比検討した. その結果, AD全例で, X線CT, MRIで明らかな異常は検出されなかったが, SPECTにて, 頭頂葉, 側頭葉, 前頭葉の各連合野に病変が検出された. PD 2例では, X線CT, MRIで, 前頭葉または側頭葉に葉性萎縮があり, SPECTではその部に一致して病変が検出された. CJD 2例では, X線CT, MRIともに正常であったが, SPECTでは連合野に限定せず, 大脳皮質全領域で病変が検出された. I-123IMP-SPECTはX線CTやMRIで検出不可能な早期の局所的機能低下を検出できるとともに, 痴呆の鑑別診断に有用な情報を提供すると考えられる. |
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| Practice | 臨床医学：一般 |
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| Keywords | N-Isopropyl I-123 p-Iodoamphetamine, Single photon emission computed tomography, Alzheimer's disease, Pick disease, Creutzfeldt-Jakob disease |
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| English |
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| Title | N-Isopropyl I-123 p-Iodoamphetamine (IMP) Brain SPECT in Dementia |
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| Authors | Toshimitsu MOMOSE*, Noboru KOSAKA*, Junichi NISHIKAWA*, Kohki YOSHIKAWA*, Tohru OHTAKE*, Toshiaki WATANABE*, Makoto IWATA**, Teruo SHIMIZU**, Masahiro IIO* |
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| Authors(kana) | |
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| Organization | *Department of Radiology, **Department of Neurology, Faculty of Medicine, University of Tokyo |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 25 |
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| Number | 12 |
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| Page | 1311-1317 |
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| Year/Month | 1988/12 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Six patients of Alzheimer's disease(AD), two patients of Pick disease(PD) and two patients of Creutzfeldt-Jakob disease(CJD) were studied with N-Isopropyl I-123 p-Iodoamphetamine(IMP) with SPECT. The pattern of IMP uptake in these demented groups were compared with that in five agematched normal controls and correlated with MRI and XCT. In all AD cases, SPECT revealed focal reduction of IMP uptake in frontal(6/6), parietal(6/6) and temporal(6/6) cortex, although MRI and XCT were normal. In both PD case, SPECT showed focal reduction of IMP uptake in frontal(1/2) and temporal(2/2) cortex with moderate labor atrophy on MRI and XCT. In both CJD case, SPECT showed diffuse reduction of IMP uptake in cerebral cortex in spite of no abnormality on MRI and XCT. These findings suggest that SPECT can detect earlier diseased process of AD and CJD than MRI or XCT and that SPECT may be helpful for the differential diagnosis of nonvascular dementia. |
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| Practice | Clinical medicine |
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| Keywords | N-Isopropyl I-123 p-Iodoamphetamine, Single photon emission computed tomography, Alzheimer's disease, Pick disease, Creutzfeldt-Jakob disease |
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