| Japanese |
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| Title | アミノ酸代謝機能診断薬としてのヨウ素標識修飾アミノ酸の可能性 - 膵臓におけるp-Iodophenylalanineのアミノ酸代謝挙動 - |
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| Subtitle | 原著 |
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| Authors | 川井恵一*, 藤林靖久**, 佐治英郎*, 小西淳二***, 横山陽* |
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| Authors(kana) | |
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| Organization | *京都大学薬学部放射性薬品化学講座, **京都大学医学部附属病院RI実験施設, ***放射線核医学科 |
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| Journal | 核医学 |
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| Volume | 25 |
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| Number | 11 |
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| Page | 1263-1270 |
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| Year/Month | 1988/11 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 膵臓における代謝機能診断用123I-標識アミノ酸放射性医薬品の開発を目的として, アミノ酸代謝挙動に対する放射性ヨウ素標識の影響を, 125I-p-ヨウ化D, L-フェニルアラニン(125I-PIPA)をモデル化合物として基礎的に検討した. 125I-PIPAは, ラット膵臓組織切片集積実験において, 母体アミノ酸である14C-L-フェニルアラニン(14C-Phe)と同種の膜能動輸送機構に基づく膵臓組織への高い集積を示した. マウス体内分布実験においても, 125I-PIPAは, 投与初期には14C-Pheと類似した体外測定の可能な膵臓への選択的な集積を示し, 診断応用への可能性を示唆した. 一方, 125I-PIPAは, タンパク合成などの滞留代謝機構に対する親和性を有していないことが示された. よって, ヨウ素標識アミノ酸である125I-PIPAは, 膵細胞膜のアミノ酸能動輸送能を選択的に評価し得る放射性医薬品である可能性が高いと考えられる. |
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| Practice | 臨床医学：一般 |
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| Keywords | Radiopharmaceutical, Radioiodinated amino acid, Pancreas, Amino acid active transport system, Single function amino acid |
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| English |
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| Title | Metabolic Studies of p-Iodophenylalanine in Pancreas : A Gateway to the Development of Radioiodinated Amino Acid for Functional Diagnosis |
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| Subtitle | |
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| Authors | Keiichi KAWAI*, Yasuhisa FUJIBAYASHI**, Hideo SAJI*, Junji KONISHI***, Akira YOKOYAMA* |
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| Authors(kana) | |
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| Organization | *Faculty of Pharmaceutical Sciences, Kyoto University, **Kyoto University Hospital, ***School of Medicine, Kyoto University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 25 |
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| Number | 11 |
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| Page | 1263-1270 |
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| Year/Month | 1988/11 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Development of radioiodinated amino acid radiopharmaceutical for functional diagnosis is most desirable. Our previous survey with natural amino acids demonstrated the great participation of L-phenylalanine in active transport system, offering the basis for the iodination. In this work, we evaluated the metabolic behavior of 125I-piodo-D, L-phenylalanine(125I-PIPA) as a model of radioiodinated amino acid comparative with 14C-L-phenylalanine(14C-Phe). As an experimental model, pancreas, an organ with high amino acid metabolic activity, was selected. The study of membrane transport system and their involvement in protein synthesis was carried out. 125I-PIPA showed high affinity for active transport system in pancreatic cell membrane to the same extend of 14C-Phe, reflected in high and specific pancreas accumulation followed by rapid clearance. Thus, 125I-PIPA has a plausible character as a single function radiopharmaceutical having high and selective affinity for active transport system in the cell membrane. |
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| Practice | Clinical medicine |
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| Keywords | Radiopharmaceutical, Radioiodinated amino acid, Pancreas, Amino acid active transport system, Single function amino acid |
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