| Japanese |
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| Title | Creutzfeldt-Jakob病のN-Isopropyl I-123 p-Iodoamphetamine SPECT |
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| Subtitle | 研究速報 |
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| Authors | 百瀬敏光*, 小坂昇*, 西川潤一*, 大嶽達*, 渡辺俊明*, 吉川宏起*, 飯尾正宏* |
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| Authors(kana) | |
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| Organization | *東京大学医学部放射線医学教室 |
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| Journal | 核医学 |
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| Volume | 25 |
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| Number | 10 |
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| Page | 1137-1141 |
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| Year/Month | 1988/10 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「I. はじめに」Creutzfeldt-Jakob病(CJD)は, 初老期から老年期に発病し, 痴呆, 意識障害, 神経症状が進行性に増悪し, 1年内外で植物状態に陥る遅発性ウィルス感染症である. 発病頻度は百万人に1人という比較的稀な病気であるが"transmissible"であり, Alzheimer病をはじめ痴呆を呈する変性疾患との関連性についての議論もあり, きわめて重要な疾患といえる. 病理学的な主な特徴は, (1)神経細胞の脱落, (2)astrocyteの増加, (3)海綿状態であるが, 臨床的には種々のvariantが存在し, 発病様式, 臨床経過は必ずしも一定ではない. この理由を病理的変化の生じる部位の違いに求めることができるが, こうした変化を生前に知ることは不可能である. これまでに, X線CTやMRIによる報告がみられるが, 局所的な異常を検出することはできていない. |
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| Practice | 臨床医学：一般 |
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| Keywords | N-Isopropyl I-123 p-Iodoamphetamine, Single photon emission computed tomography, Creutzfeldt-Jakob disease. |
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| English |
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| Title | N-Isopropyl I-123 p-Iodoamphetamine Brain Scintigraphy with SPECT in Creutzfeldt-Jakob Disease |
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| Authors | Toshimitsu MOMOSE, Noboru KOSAKA, Junichi NISHIKAWA, Tohru OHTAKE, Toshiaki WATANABE, Kohki YOSHIKAWA, Masahiro IIO |
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| Authors(kana) | |
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| Organization | Department of Radiology, Faculty of Medicine, University of Tokyo |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 25 |
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| Number | 10 |
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| Page | 1137-1141 |
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| Year/Month | 1988/10 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | Two patients of clinically diagnosed Creutzfeldt-Jakob disease (CJD) were examined with N-Isopropyl I-123 p-Iodoamphetamine (IMP) SPECT, MRI and XCT. Both patient has myoclonus and severe conscions disturbance with periodic synchronized discharge (PSD) on EEG. SPECT images were obtained using GE400AC/T. Regional IMP uptake was determined by calculating the ratio of each cortical regional to cerebellar IMP uptake [cortico-cerebellar ratio: CCR] and compared with that of five normal controls. In both case, CCR was remarkably decreased in all cortical areas, although XCT or MRI shows no abnormality except slight cortical atrophy. It suggests that metabolic and functional changes proceed morphological abnormality seen on XCT or MRI. In one case of CJD, serial studies of SPECT and XCT were performed after three months of interval. CCR in second study was higher than in first study, while XCT revealed remarkable brain atrophy including cerebrum, pons and cerebellum. It can be interpreted as regional differences of disease process. In conclusion, I-123 IMP-SPECT is useful for the earlier detection of lesions in CJD. |
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| Practice | Clinical medicine |
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| Keywords | N-Isopropyl I-123 p-Iodoamphetamine, Single photon emission computed tomography, Creutzfeldt-Jakob disease. |
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