| Japanese |
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| Title | RI標識モノクローナル抗体を用いる新しい血栓診断法に関する研究 - 第2編 放射性ヨード標識抗体による血栓シンチグラフィ - |
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| Subtitle | 原著 |
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| Authors | 中島鉄夫*, 山本和高**, 遠藤啓吾**, 阪原晴海**, 小泉満**, 河村泰孝**, 太田仁八**, 国松美帆子**, 小西淳二**, 永田博一***, 野村昌作***, 粉川晧年***, 安永幸二郎***, 松岡洋一郎****, 鳥塚莞爾***** |
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| Authors(kana) | |
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| Organization | *福井医科大学放射線科, **京都大学医学部核医学科, ***関西医科大学第一内科, ****三重大学医学部放射線科, *****副学長 |
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| Journal | 核医学 |
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| Volume | 25 |
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| Number | 10 |
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| Page | 1073-1079 |
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| Year/Month | 1988/10 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」抗血小板モノクローナル抗体を用いたイムノシンチグラフィを血栓検出に応用する目的で, ウサギを用いた基礎検討を行った. I-125標識した抗血小板抗体はin vitroで特異的にウサギ血餅に結合した. また, I-131で標識した抗血小板抗体はin vivoで血栓および脾臓によく集積し, 静注投与直後から脾臓の描出を認め, 24時間後には大腿動脈に作成した血栓がシンチグラム上陽性に描画された. また, 静注24時間後の放射活性の血栓対血液比は5.6〜25.1に達した. これに対し, 対照として用いた抗サイログロブリン抗体では何ら有意な集積を認めなかった. 以上より抗血小板モノクローナル抗体を用いたイムノシンチグラフィは, 血栓症の診断に有望な方法と思われた. 「I. はじめに」血栓症の核医学的診断法には, In-111で標識した血小板のほか, I-123・I-125・Tc-99m・Ga-67などで標識したフィブリノーゲンなどが試みられてきた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Thrombus scintigraphy, Immuno-scintigraphy, Rabbit, Monoclonal antibody, Platelet. |
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| English |
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| Title | Thrombus Scintigraphy Using Radiolabeled Monoclonal Antibodies to Platelets : (II) Visualization of Arterial Thrombus of Rabbits Using Radioiodinated Antibodies |
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| Authors | Tetsuo NAKASHIMA*, Kazutaka YAMAMOTO**, Keigo ENDO**, Harumi SAKAHARA**, Mitsuru KOIZUMI**, Yasutaka KAWAMURA**, Hitoya OOTA**, Mihoko KUNIMATSU**, Junji KONISHI**, Hirokazu NAGATA***, Syousaku NOMURA***, Hirotoshi KOKAWA***, Koujirou YASUNAGA***, Youichiro MATSUOKA****, Kanji TORIZUKA***** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, Fukui Medical School, **Department of Nuclear Medicine, Kyoto University School of Medicine, ***The First Department of Internal Medicine, Kansai Medical University, ****Department of Radiology, Mie University School of Medicine, *****Vice-President, Fukui Medical School |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 25 |
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| Number | 10 |
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| Page | 1073-1079 |
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| Year/Month | 1988/10 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | Radioiodinated monoclonal antibodies to platelets were examined for its binding to blood clot in vitro and for the thrombus scintigraphy in vivo. Experimental thrombus was produced in the femoral artery of rabbits. Specific binding of radioiodinated antibodies designated 138-10 and 1-19 was observed in vitro as well as in vivo, and both antibodies clearly visualized experimental thrombus at 6 to 24 hours after the intravenous administration. Thrombus-to-blood ratios reached 5.6-25.1 at 24 hours. On the contrary, no localization was seen with radioiodinated irrelevant antibody. These rusults indicate that immuno-scintigraphy using monoclonal antibodies to platelets is a promising tool for the localization of arterial thrombus. |
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| Practice | Clinical medicine |
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| Keywords | Thrombus scintigraphy, Immuno-scintigraphy, Rabbit, Monoclonal antibody, Platelet. |
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