| Japanese |
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| Title | single photon emission CTを用いた99mTc-PMT肝胆道シンチグラフィのdeconvolution analysisによる検討 |
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| Subtitle | 原著 |
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| Authors | 佐久間肇*, 中川毅*, 前田寿登*, 中村和義*, 竹田寛*, 権重禄**, 平野忠則*, 山口信夫* |
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| Organization | *三重大学医学部放射線科, **中国医科大学第三附属院核医学科 |
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| Journal | 核医学 |
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| Volume | 25 |
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| Number | 10 |
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| Page | 1061-1071 |
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| Year/Month | 1988/10 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」肝硬変患者12例, 健常対照例8例を対象に, SPECTを用いた99mTc-PMT肝胆道シンチグラフィのデータにdeconvolution analysisを行い肝のtransfer functionを求めた. 各画素ごとのtransfer functionから通過時間と局所有効肝血流量の分布を示すfunctional imageを作成した. その結果, 全肝および単位肝容積あたりの局所有効肝血流量と平均通過時間との間にはそれぞれ有意の逆相関が得られた(r=-0.52, r=-0.70). また, 肝硬変症例12例中3例に局所有効肝血流量の低下と排泄時間の遅延の区域性分布がみられた. 肝硬変例では一般に全肝有効肝血流量は低下し, 通過時間が延長する傾向がみられたが, 正常の通過時間を示す例も存在した. そのうち特に肝が高度の萎縮を示し, 全肝有効肝血流量は低下しているが, 局所有効肝血流量と通過時間がともに正常である例が存在した. 本法はびまん性肝疾患の病態生理の観察に有用と思われた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-PMT, Hepatobiliary imaging, SPECT, Deconvolution analysis, Effective hepatic blood flow. |
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| English |
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| Title | Three-Dimensional Functional imaging by Deconvolution Analysis in Tc-99m-PMT Hepatobiliary Dynamic SPECT Imaging |
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| Authors | Hajime SAKUMA, Tsuyoshi NAKAGAWA, Hisato MAEDA, Kazuyoshi NAKAMURA, Kan TAKEDA, Jyuroku GON, Tadanori HIRANO, Nobuo YAMAGUCHI |
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| Authors(kana) | |
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| Organization | Department of Radiology, Mie University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 25 |
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| Number | 10 |
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| Page | 1061-1071 |
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| Year/Month | 1988/10 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | Serial hepatobiliary SPECT data were analyzed by the mathematical deconvolution to derive the transfer function (TF) which represents the impulse response function of the liver following direct bolus injection. TF was obtained by matrix algorithm from regional hepatogram as output and time activity curve over the heart as input function. Minimum, mean and maximum transit time (TT), indices of excretory function, and initial height (IH), an index of effective hepatic blood flow (EHBF), were estimated from each TF. Functional images (FI) of TTs and IH were constructed by displaying these values over each element of the matrix by a color scale. In 12 cases with liver cirrhosis (LC) and 8 cases of normal controls, both total EHBF measured by blood clearance and regional EHBF estimated from FI negatively correlated with mean TT (r=-0.52, r=-0.70, respectively). In 3 cases with LC, FI showed segmental distribution of prolonged TTs with decreased IH which was hardly depicted on serial SPECT images. In cases with LC, total EHBF averaged 654+-162 ml (mean+-SD) and mean TT averaged 23.7+-3.9 min, which were significantly different from those in normal controls (1,382+-232 ml, 20.1+-2.2 min, respectively). But there were a few cases with LC that showed normal transit times and regional EHBF despite marked liver atrophy and decreased total EHBF. This method is thought to be highly valuable in evaluating pathophysiology of diffuse liver diseases because it provides three-dimensional information about effective hepatic blood flow and transit times which are combined in serial SPECT image data. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-PMT, Hepatobiliary imaging, SPECT, Deconvolution analysis, Effective hepatic blood flow. |
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