| Japanese |
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| Title | O-15標識水を用いたダイナミックポジトロンCTによる局所心筋血流量と冠動脈病変との対比 |
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| Subtitle | 原著 |
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| Authors | 高橋晶*, 小野幸彦*, 飯田秀博**, 三浦修一**, 村上松太郎**, 高橋和弘**, 菅野巖**, 宍戸文男**, 上村和夫**, 熊谷正之***, 門脇謙*** |
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| Authors(kana) | |
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| Organization | *秋田県立脳血管研究センター内科, **放射線科, ***秋田県成人病医療センター循環器科 |
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| Journal | 核医学 |
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| Volume | 25 |
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| Number | 7 |
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| Page | 647-654 |
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| Year/Month | 1988/7 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」O-15標識水を虚血性心疾患患者に瞬時静注し, ダイナミックポジトロンCTを行い局所心筋血流量の測定を試みた. 得られた局所心筋血流量値をPET測定の前2か月以内に行われた冠動脈造影上の狭窄度と対比した. 対象は正常者3例, 胸痛を有するも正常冠動脈であった5例, 安定型狭心症5例, 心筋梗塞9例である. 関心領域を左心室の, 中隔, 前壁, 側壁に設定し, 各関心領域の心筋血流量を求めた. 本法により求められた正常例における局所心筋血流量は約1.02±0.14ml/min/gであった. 正常冠動脈患者で, 0.99±0.10 ml/min/gであった. 虚血性心疾患を有する群においては, 関心領域を, 梗塞域と非梗塞域に分けた. 非梗塞域における心筋血流量は, 冠動脈造影上, 0%, 75%, 90-99%狭窄の末梢では, それぞれ0.82±0.13, 0.57±0.11, 0.67±0.17ml/min/gであり, いずれも正常冠動脈群に比べ有意に低下していた. 梗塞域における心筋血流量は冠動脈造影上, 75%, 99%狭窄の末梢では, それぞれ0.21±0.10, 0.48±0.18ml/min/gであり, いずれも正常冠動脈患者に比べ有意に低下していた. 本法の臨床的有用性は, 虚血性心疾患患者において, 安静時における心筋血流量を測定することがin vivoで可能であったということである. |
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| Practice | 臨床医学：一般 |
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| Keywords | 15O labeled water, Myocardial blood flow, Ischemic heart disease. |
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| English |
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| Title | Comparison of Quantitative Regional Myocardial Blood Flow in Patients with Ischemic Heart Disease Using Dynamic Positron Emission Tomography with Coronary Arterial Regions |
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| Subtitle | Original Articles |
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| Authors | Akira TAKAHASHI*, Yukihiko ONO*, Hidehiro IIDA**, Shuichi MIURA**, Matsutaro MURAKAMI**, Kazuhiro TAKAHASHI**, Iwao KANNO**, Fumio SHISHIDO**, Kazuo UEMURA**, Tadayuki KUMAGAI***, Ken KADOWAKI*** |
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| Authors(kana) | |
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| Organization | *Division of Internal Medicine, **Division of Radiology, Research Institute for Brain and Blood Vessels-Akita, ***Akita Medical Center |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 25 |
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| Number | 7 |
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| Page | 647-654 |
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| Year/Month | 1988/7 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] This study was performed to measure regional myocardial blood flow (MBF) in the patients with ischemic heart disease quantitatively using dynamic PET and intravenously administered O-15 water. We compared these MBF value with the degree of coronary arterial stenosis defined by coronary angiogram (CAG) performed within two months before the examination. The subjects were 3 normal volunteers, 5 patients with normal CAG, 5 patients with angina pectoris and 9 patients with myocardial infarction. The region of interest (ROI) was placed on the left ventricular wall (septum, anterior and lateral) and MBF was calculated. In normal volunteers, MBF was 1.02+-0.14 ml/min/g. In patients with normal CAG, MBF was 0.99+-0.10 ml/min/g. In IHD patients all ROIs were divided into noninfarcted and infarcted area. In the non-infarcted area MBF was 0.82+-0.13, 0.57+-0.11, 0.67+-0.17 at the distal of 0%, 75% and 90-99% stenosis, respectively. In the infarcted area MBF was 0.21+-0.10 and 0.48+-0.18 at the distal of 75% and 99% stenosis, respectively. These MBF value were significantly lower than that of normal CAG patients. The clinical advantages of this method is that we can estimate regional myocardial blood flow in patients with ischemic heart disease quantitatively in vivo. |
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| Practice | Clinical medicine |
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| Keywords | 15O labeled water, Myocardial blood flow, Ischemic heart disease. |
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