| Japanese |
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| Title | 脊髄小脳変性症における脳循環代謝測定 |
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| Subtitle | 原著 |
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| Authors | 宍戸文男*, 上村和夫*, 犬上篤*, 長田乾**, 平田温** |
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| Organization | *秋田県立脳血管研究センター放射線医学研究部, **神経内科学研究部 |
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| Journal | 核医学 |
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| Volume | 25 |
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| Number | 7 |
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| Page | 633-638 |
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| Year/Month | 1988/7 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」神経学的所見により脊髄小脳変性症と診断された10症例について, C15O2ガス, 15O2ガス, C15OガスとHEADTOME IIIを用いて, 局所脳血流量 (CBF) と局所脳酸素消費量 (CMRO2) の測定を行った. 同一断面のX線CT像を撮影し, 形態学的な萎縮の有無との関係についても検討を加えた. 8例の正常者についても同様な測定を行い, 比較検討した. 10例のいずれの症例でもCBFとCMRO2は並行した変化を示し, 両側小脳半球, 小脳虫部および脳幹部のCBFとCMRO2は正常者の値と比較して, 有意な減少がみられた. 変化は左右対称性であった. その減少の程度は症例により様々であったが, X線CTによる萎縮の程度と相関していた. 脊髄小脳変性症の診断はその特徴的な臨床症状から診断可能であるが, ポジトロンCTによりCBFとCMRO2を定量的に測定することは, 病状の程度の客観的評価, 変性の程度とその広がり, 治療効果の客観的評価などに利用可能であり, 臨床上重要な意義を持ち得ると考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Spino-cerebellar degeneration, Cerebral blood flow, Cerebral oxygen consumption, Positron emission tomography. |
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| English |
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| Title | Measurement of Cerebral Circulation and Metabolism in Patients with Spinocerebellar Degeneration Using Positron Emission Tomography and O-15 Steady-State Method |
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| Subtitle | Original Articles |
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| Authors | Fumio SHISHIDO*, Kazuo UEMURA*, Atsushi INUGAMI*, Ken NAGATA**, Yutaka HIRATA** |
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| Organization | *Department of Radiology and Nuclear Medicine, **Department of Neurology, Research Institute for Brain and Blood Vessels-Akita |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 25 |
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| Number | 7 |
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| Page | 633-638 |
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| Year/Month | 1988/7 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Ten subjects diagnosed as having spinocerebellar degeneration (SCD) were studied using positron emission tomography and O-15 steady-state method. Regions of interest were acquired for the cerebellar hemisphere, vermis, pons, corpus striata, thalami, and cerebral cortices. Eight normal volunteers served as a control group. Regional cerebral oxygen consumption (rCMRO2) was significantly decreased in the cerebellar hemispheres (reduction of 34.6% from the control value) , vermis (47.4%) and pons (48.2%) , and cerebral blood flow (rCBF) was also decreased significantly. But regional oxygen extraction fraction (rOEF) was not decreased in those areas. In both thalami (24.6%) and corpus striata (24.6%) , rCMRO2 and rCBF were mildly but significantly reduced. Cerebral cortices showed no significant reduction in rCMRO2 and rCBF. The decreases of rCBF or rCMRO2 in cerebellar hemispheres, vermis, and pons correlated significantly with the degree of the atrophic changes detected by X-ray CT. These findings suggest that the measurement of cerebral oxygen metabolism and blood flow is useful in the diagnosis of SCD. |
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| Practice | Clinical medicine |
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| Keywords | Spino-cerebellar degeneration, Cerebral blood flow, Cerebral oxygen consumption, Positron emission tomography. |
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