| Japanese |
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| Title | 123I-IMP肺シンチグラフィにおける異常集積機序の臨床的検討 |
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| Subtitle | 原著 |
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| Authors | 菅一能*, 松本常男**, 中西敬**, 横山敬**, 田中和雄***, 中村洋***, 山田典将**** |
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| Authors(kana) | |
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| Organization | *長門総合病院放射線科, **山口大学医学部放射線医学教室, ***周東総合病院放射線科, ****山口大学医学部附属病院放射線部 |
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| Journal | 核医学 |
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| Volume | 25 |
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| Number | 7 |
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| Page | 625-631 |
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| Year/Month | 1988/7 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」胸部X線単純写真上, 比較的広範囲の病変部を有する63症例に123I-IMP肺シンチグラフィを施行したところ, 静注後24時間像で全例に正常肺野より集積度の高い部位 (異常集積像) が認められた. これらの異常集積部位は, 全症例とも99mTc-MAA肺シンチグラフィの欠損域内, すなわち肺血流低下域内に存在していた. ただし腫瘍例では, 腫瘍内部はいずれも欠損を示した. また異常集積部位では, 123I-IMPの初回循環画像と静注後24時間像を比較すると, この間に, RI分布低下あるいは欠損域内に, RIの集積がみられる現象 (いわゆる再分布現象) を認めた. 肺血流低下域内に異常集積をきたす機序として, 123I-IMPが低血流量でも, いわゆるreceptorの存在する部位まで到達可能で, さらにこの部位からの洗い出しが遅延するためと推測された. すなわち, 123I-IMP肺シンチグラフィが, 99mTc-MAA肺シンチグラフィより微細な血流動態を反映する可能性が考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-IMP, 99mTc-MAA, Lung endothelial receptors, Lung cancer, Lung. |
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| English |
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| Title | Clinical Study on the Mechanism of Abnormal Accumulation in Lung Scanning with N-isopropyl-p-123I-iodoamphetamine (123I-IMP) |
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| Subtitle | Original Articles |
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| Authors | Kazuyoshi SUGA*, Tsuneo MATSUMOTO**, Takashi NAKANISHI**, Takashi YOKOYAMA**, Kazuo TANAKA***, Hiroshi NAKAMURA***, Norimasa YAMADA**** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, Nagato Sougo Hospital, **Department of Radiology, Yamaguchi University School of Medicine, ***Department of Radiology, Syutou Sougo Hospital, ****Department of Radiology, Yamaguchi University Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 25 |
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| Number | 7 |
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| Page | 625-631 |
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| Year/Month | 1988/7 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Sixty-three cases with gross abnormalities on chest radiograms were studied by lung scanning with 123I-IMP. Abnormal accumulation in comparison with the normal lung field was detected in all patients 24 hours after the intravenous injection of 123I-IMP and these sites were seen within hypoperfusion areas observed by lung scanning using 99mTc-MAA. However, no intratumoral accumulation was detected in the patients with tumor. Comparison between the image obtained after the initial distribution of 123I-IMP and that obtained 24 hours later showed that during this period, 123I-IMP accumulated in the area of decreased or no distribution of 123I-IMP. It was speculated that the area of low pulmonary blood flow showed abnormal accumulation, because even in a low blood flow, 123I-IMP reached the sites of receptor, and the wash-out from these sites was delayed. These findings indicate the possibility that lung scanning with 123I-IMP is a useful agent as assessing pulmonary blood flow. |
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| Practice | Clinical medicine |
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| Keywords | 123I-IMP, 99mTc-MAA, Lung endothelial receptors, Lung cancer, Lung. |
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