Japanese
TitleポジトロンCTによる局所心筋血流量の測定 - ジピリダモール負荷についての検討 -
Subtitle研究速報
Authors氷見寿治*, 遠藤真広**, 加賀谷秋彦*, 吉田勝哉*, 増田善昭*, 稲垣義明*, 福田寛**, 福田信男**, 飯沼武**, 山崎統四郎**, 舘野之男**
Authors(kana)
Organization*千葉大学医学部第三内科, **放射線医学総合研究所臨床研究部
Journal核医学
Volume25
Number5
Page451-454
Year/Month1988/5
Article報告
Publisher日本核医学会
Abstract「I. はじめに」 Tl-201を利用した負荷心筋シンチグラムは虚血部位の診断等に有用であり各種負荷試験等と組み合わせてひろく行われている. しかし, 各種負荷による局所心筋血流量の変化を定量的に示すことは困難であり, 健常部と病変部の画像の比較により相対的評価が行われているに過ぎない. 一方, 吉田らはN-13アンモニアをトレーサーとしてダイナミックポジトロンCTを行い, 肥大型心筋症例にFirst-pass法を用いることにより局所心筋血流量を定量的に計測できることを示している. 今回われわれはジピリダモール負荷によるN-13アンモニアを使用したダイナミックポジトロンCT検査を行い, 負荷による局所心筋血流量の変化をFirst-pass法を用いて定量的に検討した.
Practice臨床医学：一般
KeywordsPositron emission tomography, Regional myocardial blood flow, Dipyridamole.
English
TitleUsefulness of Positron Emission Tomography in the Assessment of the Effect of Dipyridamole on Regional Myocardial Blood Flow
SubtitleRapid Communications
AuthorsToshiharu HIMI*, Masahiro ENDO**, Akihiko KAGAYA*, Katsuya YOSHIDA*, Yoshiaki MASUDA*, Yoshiaki INAGAKI*, Hiroshi FUKUDA**, Nobuo FUKUDA**, Takeshi IINUMA**, Toushiro YAMAZAKI**, Yukio TATENO**
Authors(kana)
Organization*The Third Department of Internal Medicine, Chiba University School of Medicine, **The Department of Clinical Research, National Institute of Radiological Sciences
JournalThe Japanese Journal of nuclear medicine
Volume25
Number5
Page451-454
Year/Month1988/5
ArticleReport
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary] We assessed the percent changes of regional myocardial blood flow (RMBF) after infusion of dipyridamole. Positron emission tomography was performed in 3 patients with hypertrophic cardiomyopathy (HCM) , 2 normal subjects and 4 patients with myocardial infarction. N-13 ammonia was injected intravenously and fast dynamic study (1 frame=5.5 sec) was done. RMBF at rest was measured by first-pass flow model using timeactivity curves of left atrial blood pool and mid level of left ventricular myocardium. After N-13 ammonia was decayed, dipyridamole was infused intravenously (0.35-0.56 mg/kg) and during coronary hypernemia N-13 ammonia was reinjected for RMBF measurement. Dipyridamole increased RMBF in every segment from 38% to 164% (70.8+-30.8% mean+-SD) in patients with HCM and in normal subjects. In the cases of myocardial infarction mean percent changes of RMBF and SD were 5.5+-24.3% in the segments supplied by stenosed coronary arteries and in the segments supplied by non stenosed coronary arteries they were 84.1+-39.7% after hyperemia. It is concluded that positron computed tomography is useful to assess the change of RMBF induced with dipyridamole by using first-pass flow model.
PracticeClinical medicine
KeywordsPositron emission tomography, Regional myocardial blood flow, Dipyridamole.

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