| Japanese |
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| Title | 99mTc-hexamethylpropyleneamine oximeを用いた脳腫瘍, 血管腫の脳血流dynamic SPECT - 133Xe, 123I-IMPによるイメージとの比較 - |
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| Subtitle | 原著 |
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| Authors | 大西隆*, 星博昭*, 渡辺克司*, 陣之内正史*, 宇和田収*, 中野真一**, 木下和夫** |
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| Authors(kana) | |
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| Organization | *宮崎医科大学放射線科, **脳外科 |
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| Journal | 核医学 |
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| Volume | 25 |
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| Number | 5 |
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| Page | 431-439 |
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| Year/Month | 1988/5 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」脳腫瘍, 血管腫を対象に99mTc-hexamethylpropyleneamine oxime (HM-PAO) とN-isopropyl-p[123I]iodoamphetamine (IMP) による脳血流のダイナミックSPECTを行った. 対象とした症例は, 原発性脳腫瘍13例, 転移性脳腫瘍6例, 脳動静脈奇形 (AVM) 3例, 海綿状血管腫1例の合計23例である. 検査装置は島津製リング型ECT装置 (SET-020) で, データ処理は日本データジェネラル社製ミニコンピュータシステム (ECLIPSE S-120) にて行った. また, 同時期に133Xe吸入法による局所脳血流 (rCBF) の測定も行った. 検討方法は, HM-PAO (20-25 mCi) , IMP (3 mCi) を静注後0-20分における腫瘍部と対側皮質領域のactivityの比 (T/N比) を求め腫瘍別にT/N比を比較し, また133Xe吸入法によるrCBF像でのT/N比と比較した. Angioblastic meningioma, meningothelial meningioma, AVM, high grade astrocytomaでは, time activity curve (TAC) 早期において高いT/N比を示し, 静注後2分におけるT/N比はrCBF像でのT/N比と高い相関がみられ, 腫瘍部の血流程度を反映していた. 転移性脳腫瘍, low grade astrocytomaでは0-20分の間ほぼ一定のT/N比を示し, その値は異なるものの, 腫瘍の種類による一定の傾向は認められなかった. HM-PAOによるダイナミックSPECTは腫瘍の血流の評価に有用であり, T/N比はある程度, 腫瘍の性状を反映している可能性があると考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Tc-99m hexamethylpropyleneamine oxime, I-123 IMP, Xe-133, Brain Tumor, SPECT. |
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| English |
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| Title | Dynamic SPECT Using Tc-99m Hexamethylpropyleneamine Oxime in the Patients with Intracranial Mass Lesions - A Comparison with Xe-133 and IMP - |
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| Subtitle | Original Articles |
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| Authors | Takashi OHNISHI*, Hiroaki HOSHI*, Katsushi WATANABE*, Seishi JINNOUCHI*, Osamu UWADA*, Shinichi NAKANO**, Kazuo KINOSHITA** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, **Department of Neurosurgery, Miyazaki Medical College |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 25 |
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| Number | 5 |
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| Page | 431-439 |
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| Year/Month | 1988/5 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Dynamic single photon emission computed tomography (SPECT) using Tc-99m hexamethylpropyleneamine oxime (HM-PAO) and N-isopropyl-p[I-123]iodoamphetamine (IMP) was performed in 23 patients with intracranial mass lesions (primary brain tumor; 13, metastatic brain tumor; 6, arterio-venous malformation (AVM) ; 3, cavernous hemangioma; 1) . Instruments used were ring type emission computed tomography (SET-020, Shimadzu Co. ) with minicomputer system (ECLIPSE S-120, Japan Datageneral Co. ) . Dynamic scans were carried out immediately after intravenous injection of the radiopharmaceuticals (2 min. per frame ×10 frames. ) . Tumor activities (T/N ratios) were calculated in each frame compared to contralateral side. T/N ratios in the patients with angioblastic meningioma, meningothelial meningioma, AVM and high grade astrocytoma were high in early stage, and showed good correlation with those of rCBF image obstained by Xe-133 gas inhalation method (correlation coefficients were 0.9 in HM-PAO, 0.76 in IMP) , which seemed to indicate the rate of blood flow in the mass lesions. T/N ratios in metastatic brain tumors and low grade astrocytomas were constant during 0-20 min after injection and were not related to tumor types. In summary, dynamic SPECT may be useful method to evaluate the blood flows in brain tumors, and T/N ratios may reflect those of tumors. |
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| Practice | Clinical medicine |
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| Keywords | Tc-99m hexamethylpropyleneamine oxime, I-123 IMP, Xe-133, Brain Tumor, SPECT. |
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