| Japanese |
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| Title | 脊髄小脳変性症におけるN-isopropyl-p-[123I]-iodoamphetamineによるsingle photon emission computed tomography |
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| Subtitle | 原著 |
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| Authors | 小野志磨人*, 福永仁夫*, 大塚信昭*, 永井清久*, 王鋭*, 森田浩一*, 古川高子*, 村中明*, 柳元真一*, 友光達志*, 安田雄**, 寺尾章**, 森田陸司* |
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| Authors(kana) | |
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| Organization | *川崎医科大学核医学科, **神経内科 |
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| Journal | 核医学 |
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| Volume | 25 |
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| Number | 5 |
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| Page | 393-403 |
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| Year/Month | 1988/5 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」N-isopropyl-P-[123I]-iodoamphetamine (123I-IMP) によるsingle photon emission computed tomography (SPECT) を, 脊髄小脳変性症 (SCD) 16例, その他の疾患3例および正常者6例に施行した. さらにSCD 5例と正常者 6例は, TRH (2mg) 負荷後も検討し, 一部の症例では早期像のみならず後期像も得た. また, 小脳, 両側側頭葉, 後頭葉, 頭頂葉, 基底核に関心領域を設定し, その123I-IMPの放射能を, 両側前頭葉のそれで標準化した. SCDでは, 正常例に比して小脳への123I-IMPの集積は低下を示し, しかも重症度が増すとともに集積の低下は著明であった. TRH負荷後には, 正常者では小脳対前頭葉の比が減少するのに対して, SCDの5例中3例はその比が増加または不変であった. しかし, TRHがSCD例の小脳における123I-IMPのクリアランスを亢進させるか否かは不明であった. このように, TRH負荷を併用した123I-IMP SPECTは, SCDの病態を検討する上で有用な手段であると思われた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Spinocerebellar degeneration, N-isopropyl-p-[123I]-iodoamphetamine (123I-IMP) , Single photon emission computed tomography (SPECT) , TRH load. |
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| English |
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| Title | Single Photon Emission Computed Tomography Using N-isopropyl-p-[123I]-iodoamphetamine in Spinocerebellar Degeneration |
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| Subtitle | Original Articles |
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| Authors | Shimato ONO*, Masao FUKUNAGA*, Nobuaki OTSUKA*, Kiyohisa NAGAI*, Rui WANG*, Koichi MORITA*, Takako FURUKAWA*, Akira MURANAKA*, Shinichi YANAGIMOTO*, Tatsushi TOMOMITSU*, Takeshi YASUDA**, Akira TERAO**, Rikushi MORITA* |
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| Authors(kana) | |
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| Organization | *Department of Nuclear Medicine, **Department of Neurology, Kawasaki Medical School |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 25 |
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| Number | 5 |
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| Page | 393-403 |
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| Year/Month | 1988/5 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Single photon emission computed tomography (SPECT) using N-isopropyl-p-[123I]-iodoamphetamine (123I-IMP) was performed in 16 patients with spinocerebellar degeneration (SCD) , 3 patients with other disorders and 6 normal subjects. Furthermore, 5 SCD patients and 6 normals were investigated in post-administration of 2 mg TRH, and in some of them not only early but also delayed images were obtained. The 123I-IMP activity measured in region of interest over cerebella, temporal, occipital lobes and basal ganglia was normalized to the uptake in frontal lobes. SCD, in comparison to normals, showed the decreased accumulation of 123I-IMP in cerebella, with the severity increased. Three of 5 SCD revealed the increased or unchanged ratio of cerebella to frontal lobes after TRH load, while normals did the decreased ratio. However, it was uncertain whether TRH might promote the clearance of 123I-IMP in cerebella in SCD. Thus, 123I-IMP SPECT combined with TRH load appeared to be excellent tool for study of pathophysiology in SCD. |
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| Practice | Clinical medicine |
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| Keywords | Spinocerebellar degeneration, N-isopropyl-p-[123I]-iodoamphetamine (123I-IMP) , Single photon emission computed tomography (SPECT) , TRH load. |
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