Japanese
Title99mTc-DTPA-HSAによる心RIアンギオグラフィ - in vivo赤血球標識法との比較 -
Subtitle原著
Authors浜田星紀*,**, 西村恒彦*, 林田孝平*, 植原敏勇*, 片渕哲朗*, 林真*
Authors(kana)
Organization*国立循環器病センター放射線診療部, **現;大阪大学医学部放射線科
Journal核医学
Volume25
Number5
Page381-391
Year/Month1988/5
Article原著
Publisher日本核医学会
Abstract「要旨」新しく開発された99mTc-DTPA-HSAによる心RIアンギオグラフィを心疾患31例に施行し, 従来のin vivo赤血球標識法と対比し臨床的有用性を検討した. (1) Tc-HSA-D静注後5〜60分の血中カウントの変動率は10.1%で, in vivo赤血球標識法の1.0%に比し大きかった. (2) 体内臓器分布では, 肺臓・肝臓への取り込みは有意に高かったが, 全身と心・大血管系のカウント比は21±3.5%でin vivo赤血球標識法 (20.4±2.9%) と有意差は認めなかった. (3) 心電図ゲート法拡張末期像では, in vivo赤血球標識法と比べて心室のRI局在およびバックグラウンドは定量的に有意差を認めなかった. (4) Tc-HSA-Dは1回静注法により操作は簡便で, かつ診断能の高い画像が得られる. なお, 全例副作用は認められなかった.
Practice臨床医学：一般
Keywords99mTc-DTPA-HSA, 99mTc-RBC, Radionuclide cardioangiography, In vivo stability, Biodistribution.
English
TitleRadionuclide Cardioangiography Using 99mTc-DTPA-HSA in Comparison with In Vivo 99mTc-RBC Labeling
SubtitleOriginal Articles
AuthorsSeiki HAMADA*,**, Tsunehiko NISHIMURA**, Kohei HAYASHIDA**, Toshiisa UEHARA**, Tetsuro KATABUCHI**, Makoto HAYASHI**
Authors(kana)
Organization*Present institution: Department of Radiology, Osaka University School of Medicine, **Department of Radiology, National Caradiovascular Center
JournalThe Japanese Journal of nuclear medicine
Volume25
Number5
Page381-391
Year/Month1988/5
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary] 99mTc-diethylene triamine penta-acetic acid-human serum alubumin (99mTc-HSA-D) , a new radiopharmaceutical for cardiac radionuclide angiography was employed in 31 patients with cardiac diseases and was assessed for its capability of clinical usefulness comparing with the in vivo 99mTc-RBC (red blood cell) labeling method. The conclusions were as follows: (1) After taking sequential blood samples, the activity of 99mTc-HSA-D was less stable than that of in vivo 99mTc-RBC. The ratios of variation in the counts were 10.1% and 1.0%, respectively, between 5 and 60 minutes after injection. (2) The biodistribution studies demonstrated higher 99mTc-HSA-D accumulation than 99mTc-RBC in the liver and lung, and lower accumulation in the spleen, in proportion to extra-cellular space, however, the cardiovascular uptake of 99mTc-HSA-Din the whole body image (neck to mid-tight) was 21+-3.5% for 99mTc-HSA-D and 20.4+-2.9% for 99mTc-RBC. There was thus no significant difference between the cardiovascular uptakes with 99mTc-HSA-D and 99mTc-RBC. (3) Comparing the LV end-diastolic frame of the ECG-gated images between 99mTc-HSA-D and 99mTc-RBC, the statistical differences in RI localization and target-to-background ratios in LV between 99mTc-RBC and 99mTc-HSA-D was not significant. (4) In comparison with 99mTc-RBC, 99mTc-HSA-D was sufficiently useful for clinical blood pool imaging even with a single injection. No adverse reaction was observed in any of the subjects.
PracticeClinical medicine
Keywords99mTc-DTPA-HSA, 99mTc-RBC, Radionuclide cardioangiography, In vivo stability, Biodistribution.

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